Department of Operating Room Nursing, School of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran.
Department of Operating Room Technology, School of Paramedicine, Qom University of Medical Sciences, Qom, Iran; Student Research Committee, Department of Surgical Technology, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
Complement Ther Clin Pract. 2019 May;35:78-85. doi: 10.1016/j.ctcp.2019.01.016. Epub 2019 Feb 2.
Chemotherapy-induced phlebitis (CIP) is one of the most important and common complications in patients with cancer. Currently, the use of complementary methods to prevent or alleviate phlebitis symptoms has attracted great attention. In this study, we aimed to assess the effects of topical sesame oil in reducing the pain severity of CIP.
This randomized clinical trial was conducted on 60 patients with colorectal cancer afflicted with CIP. Patients received, twice a day for seven consecutive days, a 5-min massage solely (as the control group) or with 10 drops of sesame oil (as the experimental group) within the 10 cm radius of the affected site. The pain severity was evaluated by the visual analog scale on the first, third, fifth, and seventh days of the intervention.
Mean changes of the pain severity compared to the baseline were significant on the third (P = 0.009), fifth (P < 0.001), and seventh (P < 0.001) days of the intervention in favor of the experimental group. Also, a significant reduction in the pain severity both in the experimental and control groups was observed during the seven days (F = 720.66, P < 0.001); however, the decrease was more significant in the experimental group (F = 21.46, P < 0.001).
Application of massage with sesame oil as a complementary method is effective in reducing the pain severity of patients with CIP.
化疗引起的静脉炎（CIP）是癌症患者最常见和最重要的并发症之一。目前，使用补充方法预防或缓解静脉炎症状引起了广泛关注。本研究旨在评估局部芝麻油对减轻 CIP 疼痛严重程度的效果。
这是一项随机临床试验，纳入了 60 例患有 CIP 的结直肠癌患者。患者在连续 7 天内，每天接受两次 5 分钟的按摩，仅在受影响部位 10cm 半径内按摩（作为对照组）或在受影响部位 10cm 半径内按摩时加入 10 滴芝麻油（作为实验组）。在干预的第 1、3、5 和 7 天，使用视觉模拟评分法评估疼痛严重程度。
与基线相比，实验组在干预的第 3、5 和 7 天疼痛严重程度的平均变化具有统计学意义（P=0.009、P<0.001 和 P<0.001）。此外，实验组和对照组在 7 天内的疼痛严重程度均显著降低（F=720.66，P<0.001）；然而，实验组的下降更为显著（F=21.46，P<0.001）。
作为一种补充方法，芝麻油按摩的应用可有效减轻 CIP 患者的疼痛严重程度。
