羟基查维酮：一种来自槟榔叶的新型酚类抗诱变剂。
Hydroxychavicol: a new phenolic antimutagen from betel leaf.
作者信息
Amonkar A J, Nagabhushan M, D'Souza A V, Bhide S V
出版信息
Food Chem Toxicol. 1986 Dec;24(12):1321-4. doi: 10.1016/0278-6915(86)90065-7.
The phenolic compounds eugenol and hydroxychavicol were separated from betel leaf extract using C18 phase bonded Hiflosil silica gel. The structures of the two compounds were confirmed by nuclear magnetic resonance data. Neither eugenol nor hydroxychavicol was mutagenic when tested in various strains of Salmonella typhimurium with or without metabolic activation. Both compounds exhibited dose-dependent suppression of dimethylbenzanthracene-induced mutagenesis in S. typhimurium strain TA98 with metabolic activation. Hydroxychavicol was more potent than eugenol in this respect.
使用C18键合的Hiflosil硅胶从槟榔叶提取物中分离出酚类化合物丁香酚和羟基查耳酮。通过核磁共振数据确认了这两种化合物的结构。在有或没有代谢激活的情况下，在各种鼠伤寒沙门氏菌菌株中进行测试时，丁香酚和羟基查耳酮均无致突变性。在有代谢激活的情况下，这两种化合物在鼠伤寒沙门氏菌TA98菌株中均表现出对二甲基苯并蒽诱导的诱变的剂量依赖性抑制作用。在这方面，羟基查耳酮比丁香酚更有效。
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