• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一种新的水胡椒二聚体来自水烟筒的根。

A new hydroxychavicol dimer from the roots of Piper betle.

机构信息

Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.

出版信息

Molecules. 2013 Feb 26;18(3):2563-70. doi: 10.3390/molecules18032563.

DOI:10.3390/molecules18032563
PMID:23442932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6270560/
Abstract

A new hydroxychavicol dimer, 2-(g'-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

摘要

一种新的羟基胡椒酚二聚体,2-(g'-羟基胡椒酚)-羟基胡椒酚(1),从胡椒根中分离出来。与五个已知化合物,羟基胡椒酚(2),阿立洛拉他姆 A II(3),阿立洛拉他姆 B II(4),胡椒螺烷 A(5)和 Cephradione A(6)。这些分离化合物的结构通过光谱方法阐明。化合物 1 和 2 表现出对人嗜中性粒细胞中超氧阴离子生成和弹性蛋白酶释放的抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/e3b0719a2621/molecules-18-02563-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/d2c05f9ed61c/molecules-18-02563-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/87224b38390a/molecules-18-02563-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/21441a26c518/molecules-18-02563-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/e3b0719a2621/molecules-18-02563-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/d2c05f9ed61c/molecules-18-02563-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/87224b38390a/molecules-18-02563-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/21441a26c518/molecules-18-02563-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f384/6270560/e3b0719a2621/molecules-18-02563-g004.jpg

相似文献

1
A new hydroxychavicol dimer from the roots of Piper betle.一种新的水胡椒二聚体来自水烟筒的根。
Molecules. 2013 Feb 26;18(3):2563-70. doi: 10.3390/molecules18032563.
2
Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle.羟基查维酮:一种从蒌叶(Piper betle)中提取的强效黄嘌呤氧化酶抑制剂。
J Nat Med. 2009 Jul;63(3):355-9. doi: 10.1007/s11418-009-0331-y. Epub 2009 Apr 22.
3
Phytochemical Analysis, Identification and Quantification of Antibacterial Active Compounds in Betel Leaves, Piper betle Methanolic Extract.槟榔叶、蒌叶甲醇提取物中抗菌活性化合物的植物化学分析、鉴定与定量
Pak J Biol Sci. 2017;20(2):70-81. doi: 10.3923/pjbs.2017.70.81.
4
Evaluation of the antimicrobial, antioxidant, and anti-inflammatory activities of hydroxychavicol for its potential use as an oral care agent.对羟基查耳酮作为口腔护理剂的潜在用途进行抗菌、抗氧化和抗炎活性评估。
Antimicrob Agents Chemother. 2009 Jan;53(1):216-22. doi: 10.1128/AAC.00045-08. Epub 2008 Jun 23.
5
Chemical constituents of Piper betle Linn. (Piperaceae) roots.蒌叶(胡椒科)根的化学成分。
Molecules. 2005 Aug 31;10(7):798-802. doi: 10.3390/10070798.
6
Anticancer Potential of Hydroxychavicol Derived from L: An and Cytotoxicity Study.羟基胡椒酚源于辣木的抗癌潜力及细胞毒性研究。
Nutr Cancer. 2022;74(10):3701-3713. doi: 10.1080/01635581.2022.2085310. Epub 2022 Jun 15.
7
In vitro antifungal activity of hydroxychavicol isolated from Piper betle L.水芹醇分离自菝葜中体外抗真菌活性的研究
Ann Clin Microbiol Antimicrob. 2010 Feb 3;9:7. doi: 10.1186/1476-0711-9-7.
8
molecular docking for assessing anti-fungal competency of hydroxychavicol, a phenolic compound of betel leaf ( L.) against COVID-19 associated maiming mycotic infections.进行分子对接,以评估荜茇酚(槟榔叶中的一种酚类化合物)对 COVID-19 相关致残真菌感染的抗真菌能力。
Drug Dev Ind Pharm. 2022 May;48(5):169-188. doi: 10.1080/03639045.2022.2048665. Epub 2022 Aug 23.
9
The new ether derivative of phenylpropanoid and bioactivity was investigated from the leaves of L.从 L. 的叶子中研究了苯丙素类新醚衍生物及其生物活性。
Nat Prod Res. 2020 Mar;34(5):638-645. doi: 10.1080/14786419.2018.1495634. Epub 2018 Aug 31.
10
Hydroxychavicol, a polyphenol from leaf extract, induces cell cycle arrest and apoptosis in -resistant HT-29 colon cancer cells.姜酮酚,一种来源于姜科植物叶提取物的多酚,可诱导耐药 HT-29 结肠癌细胞的细胞周期停滞和凋亡。
J Zhejiang Univ Sci B. 2021 Feb 15;22(2):112-122. doi: 10.1631/jzus.B2000446.

引用本文的文献

1
Potential Piperolactam A Isolated From Piper betle as Natural Inhibitors of Brucella Species Aminoacyl-tRNA Synthetase for Livestock Infections: In Silico Approach.从菝葜中分离出的潜在哌啶酮 A 作为布鲁氏菌属氨基酸酰-tRNA 合成酶的天然抑制剂用于家畜感染:计算方法。
Vet Med Sci. 2024 Nov;10(6):e70042. doi: 10.1002/vms3.70042.
2
IL-6 Inhibitory Compounds from the Aerial Parts of and Their Anticancer Activities on Ovarian Cancer Cell Lines.从 和 的地上部分中分离得到的白细胞介素-6 抑制化合物及其对卵巢癌细胞系的抗癌活性。
Molecules. 2024 Jun 23;29(13):2981. doi: 10.3390/molecules29132981.
3
Characterization and Bioactive Potential of Secondary Metabolites Isolated from Roxb.

本文引用的文献

1
Neutrophil extracellular trap in human diseases.中性粒细胞胞外诱捕网在人类疾病中的作用
Adv Exp Med Biol. 2013;756:1-8. doi: 10.1007/978-94-007-4549-0_1.
2
Anti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: the relationships to chemical structures.槲皮素及其多甲氧基化合物和糖苷的抗炎活性和经皮吸收:与化学结构的关系。
Eur J Pharm Sci. 2012 Dec 18;47(5):857-64. doi: 10.1016/j.ejps.2012.04.024. Epub 2012 May 17.
3
Piper betel Linn (betel vine), the maligned Southeast Asian medicinal plant possesses cancer preventive effects: time to reconsider the wronged opinion.
从 Roxb. 中分离得到的次生代谢产物的特性和生物活性潜力
Int J Mol Sci. 2023 Jan 10;24(2):1328. doi: 10.3390/ijms24021328.
4
Hydroxychavicol as a potential anticancer agent (Review).羟基查耳酮作为一种潜在的抗癌剂(综述)。
Oncol Lett. 2022 Dec 5;25(1):34. doi: 10.3892/ol.2022.13620. eCollection 2023 Jan.
5
Untargeted Metabolomics in Piper betle Leaf Extracts to Discriminate the Cultivars of Coastal Odisha, India.胡椒科菝葜属植物叶提取物的非靶向代谢组学分析,以区分印度奥里萨邦沿海地区的品种。
Appl Biochem Biotechnol. 2022 Oct;194(10):4362-4376. doi: 10.1007/s12010-022-03873-0. Epub 2022 Mar 2.
6
Impact of Storage Conditions on the Stability of Predominant Phenolic Constituents and Antioxidant Activity of Dried Piper betle Extracts.储存条件对干燥荜茇提取物中主要酚类成分稳定性和抗氧化活性的影响。
Molecules. 2018 Feb 23;23(2):484. doi: 10.3390/molecules23020484.
7
Nature is the best source of anti-inflammatory drugs: indexing natural products for their anti-inflammatory bioactivity.大自然是最好的抗炎药物来源:为具有抗炎生物活性的天然产物编制索引。
Inflamm Res. 2018 Jan;67(1):67-75. doi: 10.1007/s00011-017-1096-5. Epub 2017 Sep 27.
蒌叶(Piper betel Linn),这种被误解的东南亚药用植物具有防癌作用:是时候重新审视这一被冤枉的观点了。
Asian Pac J Cancer Prev. 2011;12(9):2149-56.
4
The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation.山麦冬皂苷 SMG-1 是一种天然的 FMLP 受体抑制剂,能抑制人中性粒细胞的激活。
Biochem Pharmacol. 2010 Oct 15;80(8):1190-200. doi: 10.1016/j.bcp.2010.06.028. Epub 2010 Jun 25.
5
In vitro antifungal activity of hydroxychavicol isolated from Piper betle L.水芹醇分离自菝葜中体外抗真菌活性的研究
Ann Clin Microbiol Antimicrob. 2010 Feb 3;9:7. doi: 10.1186/1476-0711-9-7.
6
Advances in neutrophil biology: clinical implications.中性粒细胞生物学进展:临床意义
Chest. 2008 Sep;134(3):606-612. doi: 10.1378/chest.08-0422.
7
Inhibitory effects of 16-hydroxycleroda-3,13(14)E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms.16 - 羟基克罗烷 - 3,13(14)E - 二烯 - 15 - 酸通过多种机制对人中性粒细胞中超氧阴离子和弹性蛋白酶释放的抑制作用。
Eur J Pharmacol. 2008 May 31;586(1-3):332-9. doi: 10.1016/j.ejphar.2008.02.041. Epub 2008 Mar 4.
8
Chemical constituents of Piper betle Linn. (Piperaceae) roots.蒌叶(胡椒科)根的化学成分。
Molecules. 2005 Aug 31;10(7):798-802. doi: 10.3390/10070798.
9
Genetic mechanisms of susceptibility to oxidative lung injury in mice.小鼠对氧化性肺损伤易感性的遗传机制。
Free Radic Biol Med. 2007 Feb 15;42(4):433-45. doi: 10.1016/j.freeradbiomed.2006.11.021. Epub 2006 Nov 23.
10
Biotransformations of propenylbenzenes by an Arthrobacter sp. and its t-anethole blocked mutants.节杆菌对丙烯基苯的生物转化及其对甲氧基苯丙烯(茴香脑)阻断突变体
J Biotechnol. 2003 Oct 9;105(1-2):61-70. doi: 10.1016/s0168-1656(03)00141-x.