Department of Neurology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Interdisciplinary Institute of Neuroscience and Technology of Qiushi Academy for Advanced Studies, College of Biomedical Engineering and Instrument Science, Zhejiang University, Room 210, Kexue Building, Huajiachi Campus, 258 Kaixuan Rd, Jianggan District, Hangzhou, 310029, Zhejiang, China.
School of Information and Engineering, Hangzhou Dianzi University, Hangzhou, China.
Brain Struct Funct. 2019 Jun;224(5):1753-1766. doi: 10.1007/s00429-019-01880-2. Epub 2019 Apr 19.
Using oddball stimulus with pure tones, researchers have extensively investigated stimulus-specific adaptation (SSA), which has been regarded as a method of novelty detection, from the inferior colliculus (IC) to the auditory cortex (AC). However, until now, it is not clear whether SSA is preserved for natural sounds or whether it exists for spatial cues in the AC. Moreover, it is also unclear whether SSA integrates different types of cues within a single modality such as sound location and sound identity. Here, we addressed these issues using two natural sounds presented at two different locations while simultaneously performing extracellular recordings in the AC of awake rats. Our data showed that SSA was present in the AC for the natural sounds, the pure tones, and the spatial locations in the neuronal population. We also found that the AC response to a double deviant stimulus (a deviant sound at a deviant location) was stronger than that to a single (either a deviant sound or the same sound at a deviant location); this finding suggests that detecting unexpected events benefits from the integration of different cues within the same modality.
使用奇异性刺激与纯音，研究人员已经从下丘（IC）到听觉皮层（AC）广泛研究了刺激特异性适应（SSA），它被认为是一种新颖性检测方法。然而，到目前为止，还不清楚 SSA 是否适用于自然声音，或者它是否存在于 AC 中的空间线索中。此外，也不清楚 SSA 是否在单一模态（如声音位置和声音身份）内整合不同类型的线索。在这里，我们使用在两个不同位置呈现的两种自然声音，并同时在清醒大鼠的 AC 中进行细胞外记录，来解决这些问题。我们的数据表明，SSA 存在于 AC 中的自然声音、纯音和空间位置的神经元群体中。我们还发现，双变异性刺激（在变异性位置的变异性声音）的 AC 反应强于单一刺激（在变异性位置的变异性声音或相同声音）；这一发现表明，检测意外事件受益于同一模态内不同线索的整合。
