Department of Neurology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310029, China.
Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, 310027, China.
Neurosci Bull. 2022 Jul;38(7):785-795. doi: 10.1007/s12264-022-00827-8. Epub 2022 Feb 25.
Stimulus-specific adaptation (SSA), defined as a decrease in responses to a common stimulus that only partially generalizes to other rare stimuli, is a widespread phenomenon in the brain that is believed to be related to novelty detection. Although cross-modal sensory processing is also a widespread phenomenon, the interaction between the two phenomena is not well understood. In this study, the thalamic reticular nucleus (TRN), which is regarded as a hub of the attentional system that contains multi-modal neurons, was investigated. The results showed that SSA existed in an interactive oddball stimulation, which mimics stimulation changes from one modality to another. In the bimodal integration, SSA to bimodal stimulation was stronger than to visual stimulation alone but similar to auditory stimulation alone, which indicated a limited integrative effect. Collectively, the present results provide evidence for independent cross-modal processing in bimodal TRN neurons.
刺激特异性适应（SSA）是指对常见刺激的反应降低，而这种反应仅部分泛化到其他罕见刺激，这是大脑中普遍存在的现象，被认为与新颖性检测有关。尽管跨模态感觉处理也是一种普遍存在的现象，但这两种现象之间的相互作用还不是很清楚。在这项研究中，研究了丘脑网状核（TRN），它被认为是包含多模态神经元的注意系统的枢纽。结果表明，SSA 存在于模拟一种模态到另一种模态刺激变化的交互式奇特刺激中。在双模态整合中，双模态刺激的 SSA 比单独的视觉刺激更强，但与单独的听觉刺激相似，这表明整合效应有限。总之，这些结果为双模态 TRN 神经元中的独立跨模态处理提供了证据。
