神经病毒顺行性神经回路示踪。
Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses.
机构信息
Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Neurosci Bull. 2019 Oct;35(5):909-920. doi: 10.1007/s12264-019-00374-9. Epub 2019 Apr 19.
Abstract
A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal for mapping neural circuits. So far, several classes of viral neuronal tracers have become available and provide a powerful toolbox for delineating neural networks. In this paper, we review the recent developments of neurotropic viral tracers and highlight their unique properties in revealing patterns of neuronal connections.
摘要
解析神经系统在健康和疾病中的作用的一个主要目标是确定神经元的连接。神经嗜性病毒在突触连接的神经元中传播的倾向使它们成为绘制神经回路的理想工具。到目前为止，已经有几类神经嗜性病毒示踪剂可用，为描绘神经网络提供了一个强大的工具包。本文综述了神经嗜性病毒示踪剂的最新进展，并强调了它们在揭示神经元连接模式方面的独特特性。
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