Fan Lihong
Department of Preventive Medicine, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China.
Virus Genes. 2019 Aug;55(4):433-439. doi: 10.1007/s11262-019-01665-z. Epub 2019 Apr 19.
Porcine reproductive and respiratory syndrome virus (PRRSV) is the etiologic agent of porcine reproductive and respiratory syndrome (PRRS), a devastating disease of swine that poses a serious threat to the swine industry worldwide. The induction of apoptosis in host cells is suggested to be the key cellular mechanism that contributes to the pathogenesis of PRRS. Various signaling pathways have been identified to be involved in regulating PRRSV-induced apoptosis. In this review, we summarize the potential signaling pathways that contribute to PRRSV-induced apoptosis, and propose the issues that need to be addressed in future studies for a better understanding of the molecular basis underlying the pathogenesis of PRRS.
猪繁殖与呼吸综合征病毒（PRRSV）是猪繁殖与呼吸综合征（PRRS）的病原体，PRRS是一种对全球养猪业构成严重威胁的毁灭性猪病。宿主细胞凋亡的诱导被认为是导致PRRS发病机制的关键细胞机制。已确定多种信号通路参与调节PRRSV诱导的凋亡。在本综述中，我们总结了导致PRRSV诱导凋亡的潜在信号通路，并提出了未来研究中需要解决的问题，以便更好地理解PRRS发病机制的分子基础。
