Virology and Vaccine Institute of the Philippines Program, Industrial Technology Development Institute, Department of Science and Technology, Taguig, Philippines.
Department of Biology, College of Arts and Sciences, University of the Philippines Manila, Metro Manila, Philippines.
Open Vet J. 2024 Apr;14(4):941-951. doi: 10.5455/OVJ.2024.v14.i4.1. Epub 2024 Apr 30.
African swine fever virus (ASFV) poses a significant threat to global swine populations, necessitating a profound understanding of viral strategies against host antiviral innate immunity. This review synthesizes current knowledge regarding ASFV proteins and their intricate interactions with host defenses. Noteworthy findings encompass the modulation of interferon signaling, manipulation of inflammatory pathways, and the impact on cellular apoptosis. The implications of these findings provide a foundation for advancing vaccine strategies against ASFV. In conclusion, this review consolidates current knowledge, emphasizing the adaptability of ASFV in subverting host immunity. Identified research gaps underscore the need for continued exploration, presenting opportunities for developing targeted vaccines. This synthesis provides a roadmap for future investigations, aiming to enhance our preparedness against the devastating impact of ASFV on global swine populations.
非洲猪瘟病毒 (ASFV) 对全球猪群构成重大威胁，因此深入了解病毒对抗宿主抗病毒先天免疫的策略至关重要。本综述综合了目前关于 ASFV 蛋白及其与宿主防御的复杂相互作用的知识。值得注意的发现包括干扰素信号的调节、炎症途径的操纵以及对细胞凋亡的影响。这些发现的意义为开发针对 ASFV 的疫苗策略提供了基础。总之，本综述整合了当前的知识，强调了 ASFV 适应能力，以颠覆宿主免疫。确定的研究空白突出表明需要继续探索，为开发有针对性的疫苗提供了机会。这一综合为未来的研究提供了路线图，旨在提高我们对 ASFV 对全球猪群破坏性影响的防范能力。
