Gramatzki M, Nüsslein H, Burmester G R, Rödl W, Heyder N, Grote W, Monner D A, Mühlradt P F, Kalden J R
Immunobiology. 1986 Sep;172(3-5):438-47. doi: 10.1016/s0171-2985(86)80123-1.
Patients with opportunistic infections during the course of acquired immunodeficiency syndrome (AIDS) were analyzed for cellular immune functions and found to be severely immunocompromised. In particular, interleukin 2 (IL 2) production appeared to be defect not only qualitatively but also quantitatively. In some of these patients, exogenous IL 2 improved immune response in vitro. Intralymphatically administered highly purified natural IL 2 was given repeatedly (over a time period of ten days) to three of these patients. In two cases, such a treatment course was repeated later. Clinical response - at least in some patients - appeared to be of temporary benefit. Shortly after termination of IL 2 application in two patients an increase of lectin responsiveness as well as improved reactivity in skin testing was noted, encouraging further exploration of IL 2 as an immunostimulatory drug in AIDS patients.
对获得性免疫缺陷综合征（AIDS）病程中出现机会性感染的患者进行了细胞免疫功能分析，发现他们存在严重的免疫功能低下。特别是，白细胞介素2（IL-2）的产生似乎不仅在质量上而且在数量上都存在缺陷。在其中一些患者中，外源性IL-2在体外改善了免疫反应。对其中三名患者反复（在十天的时间段内）进行了经淋巴管内注射高度纯化的天然IL-2治疗。在两例患者中，这种治疗过程后来又重复进行。临床反应——至少在一些患者中——似乎有暂时的益处。在两名患者停止使用IL-2后不久，观察到凝集素反应性增加以及皮肤试验反应性改善，这鼓励进一步探索将IL-2作为AIDS患者的免疫刺激药物。
