Gramatzki M, Burmester G R, Heyder N, Nüsslein H G, Rödl W, Grote W, Monner D A, Mühlradt P F, Kalden J R
Klin Wochenschr. 1987 Apr 15;65(8):380-6. doi: 10.1007/BF01745579.
To improve immune functions in an interleukin-2 (IL-2) deficient hemophiliac AIDS patient suffering from severe Pneumocystis carinii pneumonia, treatment with IL-2 was started in addition to standard antimicrobial therapy. Highly purified IL-2 was administered subcutaneously and then repeatedly intralymphatically in a manner similar to pedal lymphography. No toxicity was observed. The patient temporarily improved clinically as well as with regard to immunological functions. Particularly the in vitro response to phytohemagglutinin (PHA) could partly be restored, and skin tests revealed improved response to recall antigens. These findings indicate that IL-2 can be administered safely and effectively by the intralymphatic route and may--in addition to antibiotics--be of value in AIDS patients with severe opportunistic infections.
为改善一名白细胞介素 -2（IL-2）缺乏的血友病艾滋病患者的免疫功能，该患者患有严重的卡氏肺孢子虫肺炎，在标准抗菌治疗的基础上开始了IL-2治疗。高纯度IL-2通过皮下给药，然后以类似于足部淋巴管造影的方式反复进行淋巴管内给药。未观察到毒性。患者在临床和免疫功能方面暂时有所改善。特别是对植物血凝素（PHA）的体外反应部分得以恢复，皮肤试验显示对回忆抗原的反应有所改善。这些发现表明，IL-2通过淋巴管内途径给药安全有效，并且除抗生素外，可能对患有严重机会性感染的艾滋病患者有价值。
