Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, F-67000 Strasbourg, France.
CIRI, International Center for Infectiology Research, Inserm, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Hospices Civils de Lyon, University of Lyon, F-69008, Lyon, France.
Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0038-2018.
Regulatory RNAs, present in many bacterial genomes and particularly in pathogenic bacteria such as , control the expression of genes encoding virulence factors or metabolic proteins. They are extremely diverse and include noncoding RNAs (sRNA), antisense RNAs, and some 5' or 3' untranslated regions of messenger RNAs that act as sensors for metabolites, tRNAs, or environmental conditions (e.g., temperature, pH). In this review we focus on specific examples of sRNAs of that illustrate how numerous sRNAs and associated proteins are embedded in complex networks of regulation. In addition, we discuss the CRISPR-Cas systems defined as an RNA-interference-like mechanism, which also exist in staphylococcal strains.
调控 RNA 存在于许多细菌基因组中，特别是在 等致病菌中，它们控制着编码毒力因子或代谢蛋白的基因表达。它们具有极高的多样性，包括非编码 RNA（sRNA）、反义 RNA，以及一些信使 RNA 的 5' 或 3' 非翻译区，它们作为代谢物、tRNA 或环境条件（例如，温度、pH 值）的传感器。在这篇综述中，我们重点介绍了 的特定 sRNA 示例，这些示例说明了许多 sRNA 及其相关蛋白如何嵌入复杂的调控网络中。此外，我们还讨论了 CRISPR-Cas 系统，它被定义为一种类似于 RNA 干扰的机制，也存在于葡萄球菌菌株中。
