调控秀丽隐杆线虫高度分支神经元形态发生的机制。
Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans.
机构信息
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.
出版信息
Dev Biol. 2019 Jul 1;451(1):53-67. doi: 10.1016/j.ydbio.2019.04.002. Epub 2019 Apr 17.
Abstract
The shape of an individual neuron is linked to its function with axons sending signals to other cells and dendrites receiving them. Although much is known of the mechanisms for axonal outgrowth, the striking complexity of dendritic architecture has hindered efforts to uncover pathways that direct dendritic branching. Here we review the results of an experimental strategy that exploits the power of genetic analysis and live cell imaging of the PVD sensory neuron in C. elegans to reveal key molecular drivers of dendrite morphogenesis.
摘要
单个神经元的形状与其功能相关联，轴突将信号发送到其他细胞，树突接收信号。尽管人们对轴突生长的机制有了很多了解，但树突结构的惊人复杂性阻碍了揭示指导树突分支形成途径的努力。在这里，我们回顾了一种实验策略的结果，该策略利用了秀丽隐杆线虫 PVD 感觉神经元的遗传分析和活细胞成像的强大功能，揭示了树突形态发生的关键分子驱动因素。
相似文献
1
Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans.调控秀丽隐杆线虫高度分支神经元形态发生的机制。
Dev Biol. 2019 Jul 1;451(1):53-67. doi: 10.1016/j.ydbio.2019.04.002. Epub 2019 Apr 17.
2
Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons.秀丽隐杆线虫感觉神经元树突形态发生所需的保守RNA结合蛋白。
G3 (Bethesda). 2015 Feb 10;5(4):639-53. doi: 10.1534/g3.115.017327.
3
Dendrite morphogenesis in Caenorhabditis elegans.秀丽隐杆线虫中的树突形态发生。
Genetics. 2024 Jun 5;227(2). doi: 10.1093/genetics/iyae056.
4
GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans.GRDN-1/Girdin调控秀丽隐杆线虫两种特殊感觉神经元类型中的树突形态发生和纤毛位置。
Dev Biol. 2021 Apr;472:38-51. doi: 10.1016/j.ydbio.2020.12.022. Epub 2021 Jan 16.
5
C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites.秀丽隐杆线虫 bicd-1 同源物，果蝇动力蛋白辅助因子 Bicaudal D 的同源物，调节 PVD 感觉神经元树突的分支。
Development. 2011 Feb;138(3):507-18. doi: 10.1242/dev.060939.
6
Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.在伤害性神经元中，独立的转录调控通路决定了不同类别的姐妹树突。
Dev Biol. 2017 Dec 15;432(2):248-257. doi: 10.1016/j.ydbio.2017.10.009. Epub 2017 Oct 13.
7
A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching.一个树突状导向受体复合物将不同的肌动蛋白调节剂聚集在一起，以驱动有效的 F-肌动蛋白组装和分支。
Dev Cell. 2018 May 7;45(3):362-375.e3. doi: 10.1016/j.devcel.2018.04.008.
8
Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans.延时成像和细胞特异性表达谱分析揭示了线虫多树突伤害感受器的动态分支和分子决定因素。
Dev Biol. 2010 Sep 1;345(1):18-33. doi: 10.1016/j.ydbio.2010.05.502. Epub 2010 Jun 9.
9
Receptor tyrosine phosphatase CLR-1 acts in skin cells to promote sensory dendrite outgrowth.受体酪氨酸磷酸酶CLR-1在皮肤细胞中发挥作用，促进感觉神经元树突的生长。
Dev Biol. 2016 May 1;413(1):60-9. doi: 10.1016/j.ydbio.2016.03.001. Epub 2016 Mar 8.
10
RABR-1, an atypical Rab-related GTPase, cell-nonautonomously restricts somatosensory dendrite branching.RABR-1，一种非典型的 Rab 相关 GTP 酶，非自主地限制躯体感觉树突分支。
Genetics. 2024 Oct 7;228(2). doi: 10.1093/genetics/iyae113.
引用本文的文献
1
The Ral small GTPase is an essential regulator of Exocyst complex function in secretion.Ral小GTP酶是分泌过程中Exocyst复合体功能的重要调节因子。
bioRxiv. 2025 Aug 31:2025.08.28.672893. doi: 10.1101/2025.08.28.672893.
2
PTEN regulates starburst amacrine cell dendrite morphology during development.在发育过程中，PTEN调节无长突星形细胞树突形态。
bioRxiv. 2025 May 8:2025.05.08.652956. doi: 10.1101/2025.05.08.652956.
3
The kinetochore protein KNL-1 regulates the actin cytoskeleton to control dendrite branching.动粒蛋白KNL-1调节肌动蛋白细胞骨架以控制树突分支。
J Cell Biol. 2025 Feb 3;224(2). doi: 10.1083/jcb.202311147. Epub 2024 Dec 3.
4
Endocytosis restricts dendrite branching via removing ectopically localized branching ligands.内吞作用通过去除异位定位的分支配体限制树突分支。
Nat Commun. 2024 Nov 7;15(1):9651. doi: 10.1038/s41467-024-53970-3.
5
High-Resolution Imaging and Morphological Phenotyping of through Stable Robotic Sample Rotation and Artificial Intelligence-Based 3-Dimensional Reconstruction.通过稳定的机器人样本旋转和基于人工智能的三维重建实现高分辨率成像和形态表型分析。
Research (Wash D C). 2024 Oct 30;7:0513. doi: 10.34133/research.0513. eCollection 2024.
6
Adjacent Neuronal Fascicle Guides Motoneuron 24 Dendritic Branching and Axonal Routing Decisions through Dscam1 Signaling.邻近神经束引导运动神经元 24 树突分支和轴突路由决策通过 Dscam1 信号。
eNeuro. 2024 Oct 22;11(10). doi: 10.1523/ENEURO.0130-24.2024. Print 2024 Oct.
7
RABR-1, an atypical Rab-related GTPase, cell-nonautonomously restricts somatosensory dendrite branching.RABR-1，一种非典型的 Rab 相关 GTP 酶，非自主地限制躯体感觉树突分支。
Genetics. 2024 Oct 7;228(2). doi: 10.1093/genetics/iyae113.
8
KLP-7/Kinesin-13 orchestrates axon-dendrite checkpoints for polarized trafficking in neurons.KLP-7/驱动蛋白-13协调轴突-树突检查点以实现神经元中的极化运输。
Mol Biol Cell. 2024 Sep 1;35(9):ar115. doi: 10.1091/mbc.E23-08-0335. Epub 2024 Jul 10.
9
Dendrite morphogenesis in Caenorhabditis elegans.秀丽隐杆线虫中的树突形态发生。
Genetics. 2024 Jun 5;227(2). doi: 10.1093/genetics/iyae056.
10
Adjacent Neuronal Fascicle Guides Motoneuron 24 Dendritic Branching and Axonal Routing Decisions through Dscam1 Signaling.相邻神经元束通过Dscam1信号引导运动神经元24树突分支和轴突路径选择。
bioRxiv. 2024 Apr 12:2024.04.08.588591. doi: 10.1101/2024.04.08.588591.
本文引用的文献
1
Actin assembly and non-muscle myosin activity drive dendrite retraction in an UNC-6/Netrin dependent self-avoidance response.肌动蛋白组装和非肌肉肌球蛋白活性驱动 UNC-6/神经导向因子依赖性树突回缩的自我回避反应。
PLoS Genet. 2019 Jun 20;15(6):e1008228. doi: 10.1371/journal.pgen.1008228. eCollection 2019 Jun.
2
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites.Atlastin-1 调节树突内质网的形态和功能。
Nat Commun. 2019 Feb 4;10(1):568. doi: 10.1038/s41467-019-08478-6.
3
TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization.TIAM-1/GEF 可以通过调节 F-actin 的定位来独立于其 GEF 活性来塑造躯体感觉树突。
Elife. 2019 Jan 29;8:e38949. doi: 10.7554/eLife.38949.
4
Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors.轴突依赖性躯体感觉树突分支的模式形成和维持。
Dev Cell. 2019 Jan 28;48(2):229-244.e4. doi: 10.1016/j.devcel.2018.12.015. Epub 2019 Jan 17.
5
Adhesive L1CAM-Robo Signaling Aligns Growth Cone F-Actin Dynamics to Promote Axon-Dendrite Fasciculation in C. elegans.黏附性 L1CAM-Robo 信号调节生长锥 F-肌动蛋白动力学，促进线虫的轴突-树突聚集。
Dev Cell. 2019 Jan 28;48(2):215-228.e5. doi: 10.1016/j.devcel.2018.10.028. Epub 2018 Dec 13.
6
Local microtubule organization promotes cargo transport in dendrites.局部微管组织促进树突中的货物运输。
J Cell Sci. 2018 Oct 22;131(20):jcs223107. doi: 10.1242/jcs.223107.
7
Actin blobs prefigure dendrite branching sites.肌动球蛋白球预成性树突分支位点。
J Cell Biol. 2018 Oct 1;217(10):3731-3746. doi: 10.1083/jcb.201711136. Epub 2018 Jul 24.
8
A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching.一个树突状导向受体复合物将不同的肌动蛋白调节剂聚集在一起，以驱动有效的 F-肌动蛋白组装和分支。
Dev Cell. 2018 May 7;45(3):362-375.e3. doi: 10.1016/j.devcel.2018.04.008.
9
Four specific immunoglobulin domains in UNC-52/Perlecan function with NID-1/Nidogen during dendrite morphogenesis in .UNC-52/Perlecan 中的四个特定免疫球蛋白结构域与 NID-1/Nidogen 一起在. 的树突形态发生中发挥作用。
Development. 2018 May 14;145(10):dev158881. doi: 10.1242/dev.158881.
10
Cell-Autonomous Regulation of Dendrite Self-Avoidance by the Wnt Secretory Factor MIG-14/Wntless.Wnt 分泌因子 MIG-14/Wntless 通过细胞自主调控树突自回避
Neuron. 2018 Apr 18;98(2):320-334.e6. doi: 10.1016/j.neuron.2018.03.031.
Zotero 插件