调控秀丽隐杆线虫高度分支神经元形态发生的机制。
Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans.
机构信息
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA.
出版信息
Dev Biol. 2019 Jul 1;451(1):53-67. doi: 10.1016/j.ydbio.2019.04.002. Epub 2019 Apr 17.
Abstract
The shape of an individual neuron is linked to its function with axons sending signals to other cells and dendrites receiving them. Although much is known of the mechanisms for axonal outgrowth, the striking complexity of dendritic architecture has hindered efforts to uncover pathways that direct dendritic branching. Here we review the results of an experimental strategy that exploits the power of genetic analysis and live cell imaging of the PVD sensory neuron in C. elegans to reveal key molecular drivers of dendrite morphogenesis.
摘要
单个神经元的形状与其功能相关联，轴突将信号发送到其他细胞，树突接收信号。尽管人们对轴突生长的机制有了很多了解，但树突结构的惊人复杂性阻碍了揭示指导树突分支形成途径的努力。在这里，我们回顾了一种实验策略的结果，该策略利用了秀丽隐杆线虫 PVD 感觉神经元的遗传分析和活细胞成像的强大功能，揭示了树突形态发生的关键分子驱动因素。
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