Hackbarth C J, Chambers H F, Stella F, Shibl A M, Sande M A
J Antimicrob Chemother. 1986 Nov;18 Suppl D:65-9. doi: 10.1093/jac/18.supplement_d.65.
The potential of ciprofloxacin for the therapy of Pseudomonas aeruginosa meningitis was evaluated in an animal model by determining the penetration of the drug into CSF, its concentration-dependent killing characteristics in vivo, and its relative efficacy compared with ceftazidime and tobramycin. Meningitis was produced in 40 rabbits by intracisternal injection of 3 X 10(7) organisms. The drugs were administered intravenously over seven hours, and simultaneously serum and CSF samples were taken at 0, 1, 3, 5, and 7 h for determination of drug concentration and CSF bacterial counts. The percentage penetration of ciprofloxacin (18.4 +/- 12.3; mean +/- standard deviation) in infected rabbits was substantially increased over that found in uninfected rabbits (4.1 +/- 1.3). The rate of bacterial killing for animals treated with ceftazidime (100 mg/kg/h) and high doses of tobramycin (2.5 mg/kg/h) was -0.51 +/- 0.13 (log10 cfu/ml/h). This was similar to the rate of killing (-0.48 +/- 0.2) found when ciprofloxacin was infused at 5 mg/kg/h, a dose that produced a mean serum level of 6.7 +/- 4.6 mg/l, which corresponds to concentrations achievable in humans. As dosages were increased (15 and 30 mg/kg/h), the rate of bacterial killing also increased (-0.70 +/- 0.1 and -0.89 +/- 0.4 respectively; r = 0.7407; P less than 0.01). The drugs shows promise in the treatment of pseudomonas meningitis.
通过测定环丙沙星在脑脊液中的渗透情况、其在体内的浓度依赖性杀菌特性以及与头孢他啶和妥布霉素相比的相对疗效，在动物模型中评估了环丙沙星治疗铜绿假单胞菌脑膜炎的潜力。通过脑池内注射3×10⁷个细菌在40只兔子中诱发脑膜炎。药物在7小时内静脉给药，同时在0、1、3、5和7小时采集血清和脑脊液样本，以测定药物浓度和脑脊液细菌计数。感染兔子中环丙沙星的渗透百分比（18.4±12.3；平均值±标准差）比未感染兔子（4.1±1.3）显著增加。用头孢他啶（100mg/kg/h）和高剂量妥布霉素（2.5mg/kg/h）治疗的动物的细菌杀灭率为-0.51±0.13（log₁₀cfu/ml/h）。这与以5mg/kg/h输注环丙沙星时的杀灭率（-0.48±0.2）相似，该剂量产生的平均血清水平为6.7±4.6mg/l，这与人类可达到的浓度相对应。随着剂量增加（15和30mg/kg/h），细菌杀灭率也增加（分别为-0.70±0.1和-0.89±0.4；r=0.7407；P＜0.01）。这些药物在治疗假单胞菌脑膜炎方面显示出前景。
