环丙沙星在细菌性脑膜炎患者脑脊液中的渗透情况。
Penetration of ciprofloxacin into cerebrospinal fluid of patients with bacterial meningitis.
作者信息
Wolff M, Boutron L, Singlas E, Clair B, Decazes J M, Regnier B
出版信息
Antimicrob Agents Chemother. 1987 Jun;31(6):899-902. doi: 10.1128/AAC.31.6.899.
Abstract
We evaluated the diffusion of ciprofloxacin into the cerebrospinal fluid (CSF) in 23 patients with bacterial meningitis or ventriculitis undergoing treatment with other antibiotics. Three successive ciprofloxacin doses of 200 mg were administered intravenously at 12-h intervals, first between days 2 and 4 and again between days 10 and 20 after the admission. Concentrations of ciprofloxacin in plasma and CSF obtained at 60, 120, 240, and 480 min after the third infusion were determined by high-performance liquid chromatography. In addition, serial samples were obtained from ventricular fluid in four patients. The concentrations of ciprofloxacin in CSF ranged from 0.35 to 0.56 micrograms/ml. These concentrations were equal to or higher than the MICs for most of the enterobacteria.
摘要
我们评估了23例正在接受其他抗生素治疗的细菌性脑膜炎或脑室炎患者中，环丙沙星向脑脊液（CSF）中的扩散情况。每隔12小时静脉注射200mg环丙沙星，连续给药三次，首次给药在入院后第2天至第4天之间，第二次在入院后第10天至第20天之间。第三次输注后60、120、240和480分钟采集的血浆和脑脊液中环丙沙星浓度，通过高效液相色谱法测定。此外，从4例患者的脑室液中采集了系列样本。脑脊液中环丙沙星浓度范围为0.35至0.56微克/毫升。这些浓度等于或高于大多数肠杆菌的最低抑菌浓度（MICs）。
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本文引用的文献
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Antimicrob Agents Chemother. 1984 Mar;25(3):319-26. doi: 10.1128/AAC.25.3.319.
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Successful treatment of Pseudomonas ventriculitis with ciprofloxacin.环丙沙星成功治疗铜绿假单胞菌性脑室炎。
J Antimicrob Chemother. 1986 Apr;17(4):535-8. doi: 10.1093/jac/17.4.535.
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