Van Croonenburg E J, Wöltgens J H, Qua C J, de Blieck-Hogervorst J M
J Biol Buccale. 1986 Dec;14(4):231-4.
The effects of a high EHDP concentration (0.125%) were measured under Intra Oral Cariogenicity Test (ICT) conditions in the presence or absence of F- (0.1%). EHDP as well as EHDP supplemented with F- inhibited the softening of enamel slabs to a similar extent as measured by microhardness. Measurements of the calcium and phosphate levels as a function of depth showed that the addition of F- to the EHDP solution further decreased mineral loss in the deeper layers. The results suggest that the inhibition of demineralization of the enamel by EHDP and F- is due to inhibition of acid production by microorganisms.
在口腔致龋性试验（ICT）条件下，于有或无氟（0.1%）存在的情况下，测定了高浓度依替膦酸二钠（EHDP，0.125%）的作用。通过显微硬度测量发现，依替膦酸二钠以及添加了氟的依替膦酸二钠对牙釉质板软化的抑制程度相似。钙和磷水平随深度变化的测量结果表明，向依替膦酸二钠溶液中添加氟进一步减少了深层的矿物质流失。结果表明，依替膦酸二钠和氟对牙釉质脱矿的抑制作用是由于抑制了微生物产酸。
