Van Croonenburg E J, Wöltgens J H, Qua C J, De Blieck-Hogervorst J M
J Biol Buccale. 1986 Sep;14(3):177-81.
Although the caries reducing effect of fluoride (F-) is very well known, the optimal fluoride concentration is still unknown. Therefore we compared the effects of a high (0.1% F-) with a low (0.025% F-) concentration under Intra Oral Cariogenicity Test (ICT) conditions using microhardness measurement and microdissection techniques with which it is possible to quantify the amount of Ca and P present in consecutive enamel layers. No significant differences could be demonstrated between high and low fluoride concentrations in the mineral loss in the surface layer as well as in penetration depth measured perpendicularly to the surface. The reduction of mineral loss after ICT was more pronounced with high fluoride concentrations especially in layers deeper than 150 microns. Using 0.025% F- this effect was restricted more towards the surface. Concomitantly with both F- concentrations a higher Ca/P ratio was observed compared to the sucrose treated or untreated controls.
尽管氟化物（F-）的防龋作用广为人知，但其最佳浓度仍不清楚。因此，我们在口腔致龋性试验（ICT）条件下，采用显微硬度测量和显微切割技术，比较了高浓度（0.1% F-）和低浓度（0.025% F-）氟化物的效果，利用这些技术可以量化连续釉质层中钙和磷的含量。在表层矿物质损失以及垂直于表面测量的渗透深度方面，高氟浓度和低氟浓度之间未显示出显著差异。ICT后，高氟浓度下矿物质损失的减少更为明显，尤其是在深度超过150微米的层中。使用0.025% F-时，这种效果更多地局限于表面。与两种氟浓度相伴的是，与蔗糖处理或未处理的对照组相比，观察到更高的钙/磷比。
