Wöltgens J H, Qua C, de Blieck-Hogervorst J M
J Biol Buccale. 1984 Dec;12(4):339-48.
The effect of anticalculus agent EHDP (0.05%) on caries has been studied in the presence and absence of 0.1% F- under the conditions Intra Oral Cariogenicity Test (ICT). Whereas EHDP had no influence on the change in microhardness of the produced by sucrose in the presence of absence of fluoride, it increased the F- effect inside the lesion thereby preventing the formation of minerals with a mol Ca/P ratio deviating from apatite. The EHDP effect was additioned to the F- effect demonstrating that both components act independently of one other. In this respect it has been suggested that 0.05% EHDP acts mainly on demineralization by decreasing the acid production of the micro-organisms whereas F- stimulates remineralization particularly by acting on the enamel surface.
在口腔致龋性试验（ICT）条件下，研究了抗牙结石剂EHDP（0.05%）在有和没有0.1%氟存在时对龋齿的影响。在有或没有氟的情况下，EHDP对蔗糖产生的显微硬度变化没有影响，但它增加了病变内部的氟效应，从而防止形成钙磷摩尔比偏离磷灰石的矿物质。EHDP的作用与氟效应相加，表明这两种成分相互独立起作用。在这方面，有人提出0.05%的EHDP主要通过降低微生物的产酸量来作用于脱矿，而氟则特别通过作用于牙釉质表面来刺激再矿化。
