Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, 1275 York Avenue, Box 9, New York, NY 10065, USA.
Infectious Disease Service, Department of Medicine, Weill Cornell Medical College, 275 York Avenue, Box 420, New York, NY 10065, USA.
Infect Dis Clin North Am. 2019 Jun;33(2):593-609. doi: 10.1016/j.idc.2019.02.007.
Patients with hematologic malignancy or those who undergo hematopoietic stem cell transplantation experience variable degrees of immunosuppression, dependent on underlying disease, therapy received, time since transplant, and complications, such as graft-versus-host disease. Vaccination is an important strategy to mitigate onset and severity of certain vaccine-preventable illnesses, such as influenza, pneumococcal disease, or varicella zoster infection, among others. This article highlights vaccines that should and should not be used in this patient population and includes general guidelines for timing of vaccination administration and special considerations in the context of newer therapies, recent vaccine developments, travel, and considerations for household contacts.
患有血液系统恶性肿瘤或接受造血干细胞移植的患者会经历不同程度的免疫抑制，具体取决于基础疾病、接受的治疗、移植时间以及移植物抗宿主病等并发症。接种疫苗是减轻某些可通过疫苗预防的疾病（如流感、肺炎球菌病或水痘带状疱疹感染等）的发病和严重程度的重要策略。本文重点介绍了应在该患者人群中使用和不应使用的疫苗，并包括接种疫苗的时间安排的一般指南，以及在新疗法、最近疫苗开发、旅行和家庭接触者方面的特殊考虑因素。
