Universidade Federal da Bahia (UFBA), Instituto de Ciências da Saúde, Programa de Pós-Graduação em Processos Interativos dos Órgãos e Sistemas, Salvador, BA, Brazil; Centro Universitário Estácio da Bahia, Salvador, BA, Brazil.
Universidade Federal da Bahia (UFBA), Escola de Nutrição, Departamento de Ciência da Nutrição, Salvador, BA, Brazil.
J Pediatr (Rio J). 2020 Jul-Aug;96(4):439-446. doi: 10.1016/j.jped.2019.02.005. Epub 2019 Apr 18.
To investigate the occurrence of sarcopenia in children and adolescents with chronic liver disease.
A series of cases, with patients aged 6-19 years of both genders, who were treated in Liver Outpatient Clinics. Weight, height, muscle strength (assessed by manual grip strength), and muscle mass (estimated through dual-energy X-ray absorptiometry) were measured. Sarcopenia was diagnosed based on the simultaneous presence of muscle mass and muscle strength déficits, defined as the values below the mean for muscle mass and strength of the studied population, according to gender. A descriptive analysis (mean and standard deviation) was performed, and the difference of means was calculated by Student's t-test.
A total of 85 patients were studied, mostly females (64.7%), with a mean age of 11.7 (SD=3.4) years. Sarcopenia was identified in 40% of the patients. Muscle strength déficit was found in 54.1% of the subjects, and 50.6% showed muscle mass déficit. The mean muscle mass for males was higher than that for females (6.07; SD=1.22kg/mvs. 5.42; SD=1.10kg/m; p=0.016). However, there was no significant difference in sex-related muscle strength (male=0.85; SD=0.52kgf/kgm and female=0.68; SD=0.30kgf/kgm; p=0.113).
The research findings identified that sarcopenia is a condition found in pediatric patients treated at a public referral institution for chronic liver disease.
研究慢性肝病儿童和青少年中肌少症的发生情况。
对在肝病门诊就诊的 6-19 岁的男性和女性患者进行了一系列病例研究。测量体重、身高、肌肉力量（通过手动握力评估）和肌肉量（通过双能 X 射线吸收法估计）。根据性别，根据肌肉量和肌肉力量同时存在缺陷的情况诊断肌少症，定义为低于研究人群的肌肉量和力量的平均值。进行描述性分析（平均值和标准差），并通过学生 t 检验计算平均值的差异。
共研究了 85 名患者，其中大多数为女性（64.7%），平均年龄为 11.7（SD=3.4）岁。40%的患者存在肌少症。54.1%的患者存在肌肉力量缺陷，50.6%的患者存在肌肉量缺陷。男性的平均肌肉量高于女性（6.07；SD=1.22kg/m 对 5.42；SD=1.10kg/m；p=0.016）。然而，男女之间的肌肉力量差异无统计学意义（男性=0.85；SD=0.52kgf/kgm，女性=0.68；SD=0.30kgf/kgm；p=0.113）。
研究结果表明，肌少症是在一家公立医院就诊的慢性肝病儿科患者中发现的一种病症。
