Lehman W
J Muscle Res Cell Motil. 1986 Dec;7(6):537-49. doi: 10.1007/BF01753570.
Electron microscopy demonstrates that thin filaments isolated from chicken gizzard smooth muscle in the absence of Ca2+ are aggregated into networks. In contrast, thin filaments isolated in the presence of Ca2+ are dissociated from each other. Electron microscopy also reveals that the respective state of aggregation in each type of preparation is reversible and dependent on Ca2+ concentration. Corresponding viscosity measurements indicate that network formation is associated with an increase in thin filament viscosity. We propose that thin filament aggregation in vivo may be responsible for the tension maintenance of smooth muscle during relaxation.
电子显微镜显示，在没有Ca2+的情况下从鸡胗平滑肌中分离出的细肌丝聚集成网络。相比之下，在有Ca2+的情况下分离出的细肌丝则相互解离。电子显微镜还显示，每种制剂中的各自聚集状态是可逆的，并且取决于Ca2+浓度。相应的粘度测量表明，网络形成与细肌丝粘度的增加有关。我们提出，体内细肌丝聚集可能是平滑肌在舒张过程中维持张力的原因。
