小鼠体内的环氧化酶抑制作用增强了针对吸入性蛋白酶变应原和白细胞介素-33的适应性和先天性免疫反应。 - Suppr

Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33.

作者信息

Maruyama Natsuko, Takai Toshiro, Kamijo Seiji, Suchiva Punyada, Ohba Mai, Takeshige Tomohito, Suzuki Mayu, Hara Mutsuko, Matsuno Kei, Harada Sonoko, Harada Norihiro, Nakae Susumu, Sudo Katsuko, Okuno Toshiaki, Yokomizo Takehiko, Ogawa Hideoki, Okumura Ko, Ikeda Shigaku

机构信息

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

出版信息

Allergy. 2019 Nov;74(11):2237-2240. doi: 10.1111/all.13831. Epub 2019 Jul 15.

DOI:10.1111/all.13831

PMID:31006115

Abstract

摘要

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Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33.小鼠体内的环氧化酶抑制作用增强了针对吸入性蛋白酶变应原和白细胞介素-33的适应性和先天性免疫反应。

Allergy. 2019 Nov;74(11):2237-2240. doi: 10.1111/all.13831. Epub 2019 Jul 15.

Fibrinogen cleavage products and Toll-like receptor 4 promote the generation of programmed cell death 1 ligand 2-positive dendritic cells in allergic asthma.纤维蛋白原裂解产物和 Toll 样受体 4 促进过敏性哮喘中程序性死亡受体 1 配体 2 阳性树突状细胞的生成。

J Allergy Clin Immunol. 2018 Aug;142(2):530-541.e6. doi: 10.1016/j.jaci.2017.09.019. Epub 2017 Oct 14.

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.2 型固有淋巴细胞促进局部而非全身 TH2 诱导性过敏原暴露的致敏。

J Allergy Clin Immunol. 2014 Apr;133(4):1142-8. doi: 10.1016/j.jaci.2014.02.033.

T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice.在小鼠的屋尘螨诱导的过敏性气道炎症中，T细胞对于2型固有淋巴细胞（ILC2）的激活是必需的。

Eur J Immunol. 2016 Jun;46(6):1392-403. doi: 10.1002/eji.201546119. Epub 2016 May 12.

IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.IL-33 介导体液免疫和适应性免疫细胞促进蛋白酶过敏原诱导的过敏性气道炎症的最大反应。

J Immunol. 2013 May 1;190(9):4489-99. doi: 10.4049/jimmunol.1201212. Epub 2013 Apr 1.

Type 2 innate lymphoid cells: at the cross-roads in allergic asthma.2型固有淋巴细胞：过敏性哮喘的十字路口

Semin Immunopathol. 2016 Jul;38(4):483-96. doi: 10.1007/s00281-016-0556-2. Epub 2016 Mar 10.

MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation.miRNA-155 是 2 型先天淋巴细胞和 IL-33 信号在过敏性气道炎症实验模型中的关键调节因子。

J Allergy Clin Immunol. 2017 Mar;139(3):1007-1016.e9. doi: 10.1016/j.jaci.2016.06.035. Epub 2016 Aug 1.

Aspergillus fumigatus proteases, Asp f 5 and Asp f 13, are essential for airway inflammation and remodelling in a murine inhalation model.烟曲霉蛋白酶，Asp f 5 和 Asp f 13，在小鼠吸入模型中对于气道炎症和重塑是必需的。

Clin Exp Allergy. 2015 May;45(5):982-993. doi: 10.1111/cea.12426.

Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms.环氧化酶抑制通过依赖CD4但不依赖STAT6的机制增强过敏性炎症。

J Immunol. 2005 Jan 1;174(1):525-32. doi: 10.4049/jimmunol.174.1.525.

Distinct roles of vascular endothelial growth factor receptor-1- and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung.血管内皮生长因子受体-1 和受体-2 介导的信号通路在肺内含脂多糖变应原诱导 T 细胞启动和 Th17 极化中的不同作用。

J Immunol. 2010 Nov 1;185(9):5648-55. doi: 10.4049/jimmunol.1001713. Epub 2010 Oct 4.

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Antigen Protease Activity on Intact or Tape-Stripped Skin Induces Acute Itch and T Helper Sensitization Leading to Airway Eosinophilia in Mice.完整或胶带剥离皮肤表面的抗原蛋白酶活性可诱发急性瘙痒和辅助性T细胞致敏，进而导致小鼠气道嗜酸性粒细胞增多。

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Thiophene-Based Compounds with Potential Anti-Inflammatory Activity.具有潜在抗炎活性的噻吩基化合物。

Pharmaceuticals (Basel). 2021 Jul 19;14(7):692. doi: 10.3390/ph14070692.

Inhibition of Both Cyclooxygenase-1 and -2 Promotes Epicutaneous Th2 and Th17 Sensitization and Allergic Airway Inflammation on Subsequent Airway Exposure to Protease Allergen in Mice.在随后的气道暴露于蛋白酶变应原时，抑制环氧化酶-1 和 -2 均可促进经皮致敏的 Th2 和 Th17 反应以及过敏性气道炎症。

Int Arch Allergy Immunol. 2021;182(9):788-799. doi: 10.1159/000514975. Epub 2021 Apr 19.

Lipid-mediated innate lymphoid cell recruitment and activation in aspirin-exacerbated respiratory disease.脂代谢介导向心性固有淋巴细胞募集和激活在阿司匹林加重的呼吸道疾病中的作用。

Ann Allergy Asthma Immunol. 2021 Feb;126(2):135-142. doi: 10.1016/j.anai.2020.09.011. Epub 2020 Sep 17.

COX Inhibition Increases -Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice.COX 抑制增强了 - 诱导的肺群 2 先天淋巴细胞反应和 IL-33 的释放在小鼠中。

J Immunol. 2020 Aug 15;205(4):1157-1166. doi: 10.4049/jimmunol.1901544. Epub 2020 Jul 20.

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Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33.

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