丙型肝炎病毒感染与冠状动脉疾病风险：一项荟萃分析。
Hepatitis C virus infection and risk of coronary artery disease: A meta-analysis.
机构信息
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
出版信息
Eur J Intern Med. 2019 May;63:69-73. doi: 10.1016/j.ejim.2019.03.004. Epub 2019 Apr 18.
BACKGROUND
A few recent studies have demonstrated that hepatitis C virus (HCV) infection was associated with coronary artery diseases (CAD). However, there still existed studies did not confirm this correlation.
OBJECTIVE
The objective of this study was to evaluate the association between HCV infection and CAD using a meta-analysis.
METHODS
Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) and relative risk (RR) with 95% confidence interval (CI) were calculated using the fixed and random effects models.
RESULTS
Eight cohort studies and six case-control and cross-sectional studies were enrolled in this meta-analysis. In the cohort studies, the overall RR and 95% CIs of HCV infection for CAD was 1.25, 1.12-1.40 in random effects model. For the case-control and cross-sectional studies, the overall OR and 95% CIs of HCV infection for CAD were 1.94, 1.58-2.38 in fixed effects model. No publication bias was found in this meta-analysis.
CONCLUSIONS
This meta-analysis showed that HCV infection was a risk factor for CAD.
背景
一些最近的研究表明丙型肝炎病毒（HCV）感染与冠状动脉疾病（CAD）有关。然而，仍有研究未能证实这种相关性。
目的
本研究旨在通过荟萃分析评估 HCV 感染与 CAD 之间的关联。
方法
系统检索了 Pubmed、Embase 和 Cochrane 图书馆数据库。由两名独立评审员提取数据，并使用固定效应模型和随机效应模型计算合并的比值比（OR）和相对风险（RR）及其 95％置信区间（CI）。
结果
本荟萃分析纳入了 8 项队列研究和 6 项病例对照和横断面研究。在队列研究中，HCV 感染与 CAD 的总体 RR 和 95％CI 为 1.25，在随机效应模型中为 1.12-1.40。对于病例对照和横断面研究，HCV 感染与 CAD 的总体 OR 和 95％CI 在固定效应模型中为 1.94，1.58-2.38。本荟萃分析未发现发表偏倚。
结论
本荟萃分析表明，HCV 感染是 CAD 的一个危险因素。
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