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恙虫病一例中的长节段脊髓炎、脑膜脑炎和轴索性多发性神经病

Long-Segment Myelitis, Meningoencephalitis, and Axonal Polyneuropathy in a Case of Scrub Typhus.

作者信息

Tandon Ruchika, Kumar Amit, Kumar Ajay

机构信息

Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

出版信息

Ann Indian Acad Neurol. 2019 Apr-Jun;22(2):237-240. doi: 10.4103/aian.AIAN_66_18.

Abstract

Scrub typhus, a mite-borne zoonotic disease, is endemic in several parts of India. It may cause multisystemic disease involving lungs, heart, spleen, liver, hematological system, and nervous system. Neurological involvement may include meningoencephalitis, cerebellitis, cranial nerve palsies, plexopathy, transverse myelitis, muscle dysfunction, neuroleptic malignant syndrome, parkinsonian syndrome, and Guillain-Barre syndrome. Here, we report a rare patient of scrub typhus, who developed meningoencephalitis followed by long-segment myelitis and axonal polyneuropathy, with hepatic, renal, hematological, and pulmonary involvement, following acute febrile illness with associated neurocysticercosis. He gained consciousness with a resolution of almost all of his complaints, with the exception of muscular power, which showed partial improvement following treatment with doxycycline, azithromycin, and steroids. What needs to be explored is whether the existence of neurological scrub typhus with neurocysticercosis is the coincidental price paid for living in the tropics or there is something more to it as in case of Japanese encephalitis and neurocysticercosis co-infection.

摘要

恙虫病是一种由螨传播的人畜共患病,在印度的几个地区流行。它可能导致多系统疾病,累及肺、心脏、脾脏、肝脏、血液系统和神经系统。神经系统受累可能包括脑膜脑炎、小脑炎、颅神经麻痹、神经丛病、横贯性脊髓炎、肌肉功能障碍、抗精神病药物恶性综合征、帕金森综合征和格林-巴利综合征。在此,我们报告一例罕见的恙虫病患者,在急性发热性疾病伴发神经囊尾蚴病后,出现脑膜脑炎,随后发展为长节段脊髓炎和轴索性多发性神经病,并伴有肝脏、肾脏、血液和肺部受累。除肌肉力量外,他几乎所有的症状都得到缓解并恢复了意识,在接受强力霉素、阿奇霉素和类固醇治疗后,肌肉力量有部分改善。需要探讨的是,伴有神经囊尾蚴病的神经型恙虫病的存在,是生活在热带地区所付出的巧合代价,还是像日本脑炎和神经囊尾蚴病合并感染那样另有隐情。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/843b/6472236/bac92a380fb9/AIAN-22-237-g001.jpg

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