一项比较富血小板血浆与米诺地尔治疗雄激素性脱发疗效的研究。
A Study to Compare the Efficacy of Platelet-rich Plasma and Minoxidil Therapy for the Treatment of Androgenetic Alopecia.
作者信息
Verma Kuldeep, Tegta Gita Ram, Verma Ghanshyam, Gupta Mudita, Negi Ajeet, Sharma Reena
机构信息
Department of Dermatology, Venereology and Leprosy, IGMC, Shimla, Himachal Pradesh, India.
出版信息
Int J Trichology. 2019 Mar-Apr;11(2):68-79. doi: 10.4103/ijt.ijt_64_18.
BACKGROUND
Androgenetic alopecia (AGA) is the most common cause of hair loss in men with limited treatment options. Platelet-rich plasma (PRP) therapy is one of the newer treatment options in the management of AGA which has shown promising results.
AIMS AND OBJECTIVES
This study was aimed at comparing the clinical efficacy of PRP therapy with minoxidil therapy.
MATERIALS AND METHODS
In the study, patients were randomized into two groups - Group A (given PRP therapy) and Group B (given minoxidil therapy). Both groups were followed up over a period of 6 months, and final analysis was done with the help of global photography, hair pull test, standardized hair growth questionnaire, patient satisfaction score; in addition, a comparison of platelet counts in PRP was done, to know that if a clinical correlation exists between platelet concentration and clinical improvement. A total of 40 patients clinically diagnosed with AGA were enrolled in the study with 20 patients in each group. Four patients from Group A (PRP) and six patients from Group B (minoxidil) could not complete the treatment for 6 months and were eventually excluded.
RESULTS
At the end of 6 months, 30 patients were evaluated to compare the efficacy of intradermal PRP and topical minoxidil therapy. On global photography, Group A (PRP) was found to have a comparatively better outcome than Group B (minoxidil). In hair pull test, hair growth questionnaire, and patient satisfaction score, Group A was found to be better than Group B. Mean platelet count at baseline was 3.07 ± 0.5 lac/mm, 3 while platelet count in final PRP prepared was 12.4 ± 1.7 lac/mm, and patients with a higher platelet count in PRP had a much better clinical improvement compared to patients with a low platelet count in PRP. Side effects with PRP therapy were minimal with better results which may improve the compliance of the patient.
CONCLUSION
PRP therapy can be a valuable alternative to topical minoxidil therapy in the treatment of AGA.
背景
雄激素性脱发（AGA）是男性脱发最常见的原因，治疗选择有限。富血小板血浆（PRP）疗法是AGA治疗中较新的治疗选择之一，已显示出有前景的结果。
目的
本研究旨在比较PRP疗法与米诺地尔疗法的临床疗效。
材料与方法
在该研究中，患者被随机分为两组——A组（接受PRP疗法）和B组（接受米诺地尔疗法）。两组均随访6个月，并借助整体摄影、拔毛试验、标准化头发生长问卷、患者满意度评分进行最终分析；此外，对PRP中的血小板计数进行比较，以了解血小板浓度与临床改善之间是否存在临床相关性。共有40例临床诊断为AGA的患者纳入该研究，每组20例。A组（PRP）的4例患者和B组（米诺地尔）的6例患者未能完成6个月的治疗，最终被排除。
结果
6个月末，对30例患者进行评估以比较皮内PRP和外用米诺地尔疗法的疗效。在整体摄影中，发现A组（PRP）的结果比B组（米诺地尔）相对更好。在拔毛试验、头发生长问卷和患者满意度评分方面，发现A组优于B组。基线时平均血小板计数为3.07±0.5万/mm³，而最终制备得到的PRP中的血小板计数为12.4±1.7万/mm³，与PRP中血小板计数低的患者相比，PRP中血小板计数高的患者临床改善情况要好得多。PRP疗法的副作用最小，效果更好，这可能会提高患者的依从性。
结论
在AGA的治疗中，PRP疗法可以成为外用米诺地尔疗法的一种有价值的替代方法。
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