Department of Dermatology, College of Medicine, King Faisal University, Kingdom of Saudi Arabia.
Indian J Dermatol Venereol Leprol. 2013 Sep-Oct;79(5):613-25. doi: 10.4103/0378-6323.116730.
Androgenetic alopecia (AGA) is one of the commonest reasons for dermatological consultation. Over the last few years our understanding of the pathophysiology of AGA has improved and this has paved way for better diagnostic and therapeutic options. Recent research has dwelled on the role of stem cells in the pathophysiology of AGA and has also identified newer genetic basis for the condition. Dermoscopy/trichoscopy has emerged as a useful diagnostic tool for AGA. While the major treatment options continue to be topical minoxidil, systemic Finasteride and hair transplantations, newer modalities are under investigation. Specific diagnostic and treatment recommendations have also been developed on evidence based principles. This article reviews the recent concepts in relation to AGA. With regards to the pathophysiology we have tried to stress on recent knowledge of the molecular and genetic basis of AGA. We have emphasized on an evidence based approach for treatment and diagnosis.
男性型脱发(AGA)是皮肤科最常见的就诊原因之一。在过去的几年中,我们对 AGA 的病理生理学的理解已经得到了改善,这为更好的诊断和治疗选择铺平了道路。最近的研究集中在干细胞在 AGA 的病理生理学中的作用,并确定了该病的新的遗传基础。皮肤镜/毛发镜检查已成为 AGA 的一种有用的诊断工具。虽然主要的治疗方法仍然是局部米诺地尔、全身非那雄胺和毛发移植,但新的方法正在研究中。还根据循证原则制定了特定的诊断和治疗建议。本文综述了 AGA 的最新概念。就病理生理学而言,我们试图强调 AGA 的分子和遗传基础的最新知识。我们强调了循证的治疗和诊断方法。