Kofi Boniface, Mossoro-Kpinde Christian Diamant, Mboumba Bouassa Ralph-Sydney, Péré Hélène, Robin Leman, Gresenguet Gérard, Bélec Laurent
Laboratoire National de Biologie Clinique et de Santé Publique, Bangui, Central African Republic.
2Faculté des Sciences de la Santé, Université de Bangui, Bangui, Central African Republic.
Infect Agent Cancer. 2019 Apr 8;14:9. doi: 10.1186/s13027-019-0225-x. eCollection 2019.
We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0.74% (95% CI: 0.0-2.2). Among the 29 cervical cancer samples, 19 (65.5%; 95% CI: 48.2-82.8) were positive for HPV. These results indicate that HNC are infrequently associated with HPV infection in the Central African Republic.
我们通过巢式聚合酶链反应（PCR）和核苷酸测序分析，对2009年至2017年间在中非共和国首都班吉的国家临床生物学和公共卫生实验室接受诊断的135例头颈癌（HNC）和29例宫颈癌的福尔马林固定、石蜡包埋活检组织进行了HPV患病率和基因型分布的回顾性研究。一份口咽鳞状细胞癌样本HPV 16型呈阳性。头颈癌活检组织中HPV总体患病率为0.74%（95%置信区间：0.0 - 2.2）。在29例宫颈癌样本中，19例（65.5%；95%置信区间：48.2 - 82.8）HPV呈阳性。这些结果表明，在中非共和国，头颈癌与HPV感染的关联并不常见。
