Zhang Xiaoxia, Zou Xinrong, Li Yuting, Wang Yuping
Department of Ophthalmology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China.
Department of Ophthalmology, Shanghai Fengcheng Hospital, Shanghai 200000, P.R. China.
Exp Ther Med. 2019 May;17(5):4132-4138. doi: 10.3892/etm.2019.7444. Epub 2019 Mar 26.
The long non-coding (lnc)RNA B-Raf proto-oncogene, serine/threonine kinase-activated non-protein coding RNA (BANCR) is a well-characterized oncogene, while its potential functions in other diseases remain elusive. In the present study, the possible association of BANCR with diabetic retinopathy was investigated. A total of 244 patients with diabetes were followed up every 6 months for 8 years to record the occurrence of retinopathy. A total of 38 patients developed diabetic retinopathy. During the follow-up, the plasma levels of lncRNA BANCR decreased in those patients with diabetic retinopathy but not in those with other complications or without any complications. The plasma levels of lncRNA BANCR at 12 months prior to the diagnosis of diabetic retinopathy are able to sufficiently distinguish diabetic retinopathy patients from healthy controls and diabetic patients without any obvious complications. , high-glucose treatment failed to affect the expression of lncRNA BANCR in the human retinal pigment epithelial cell line ARPE-19. However, lncRNA BANCR overexpression inhibited the apoptosis of ARPE-19 cells under high-glucose conditions. Therefore, it is indicated that lncRNA BANCR participates in the development of retinopathy in diabetic patients through its regulatory role in cell apoptosis, and may serve as a novel prognostic indicator and therapeutic target.
长链非编码（lnc）RNA B-Raf原癌基因丝氨酸/苏氨酸激酶激活的非蛋白质编码RNA（BANCR）是一种已被充分表征的癌基因，而其在其他疾病中的潜在功能仍不清楚。在本研究中，调查了BANCR与糖尿病视网膜病变之间可能的关联。对总共244例糖尿病患者每6个月进行一次为期8年的随访，以记录视网膜病变的发生情况。共有38例患者发生了糖尿病视网膜病变。在随访期间，糖尿病视网膜病变患者的lncRNA BANCR血浆水平下降，而其他并发症患者或无任何并发症患者的血浆水平未下降。在诊断糖尿病视网膜病变前12个月时，lncRNA BANCR的血浆水平能够充分区分糖尿病视网膜病变患者与健康对照以及无任何明显并发症的糖尿病患者。高糖处理未能影响人视网膜色素上皮细胞系ARPE-19中lncRNA BANCR的表达。然而，lncRNA BANCR过表达抑制了高糖条件下ARPE-19细胞的凋亡。因此，表明lncRNA BANCR通过其对细胞凋亡的调节作用参与糖尿病患者视网膜病变的发生发展，并且可能作为一种新的预后指标和治疗靶点。
