Kyncl Martin, Lestak Jan, Tintera Jaroslav, Haninec Pavel
JL Clinic, 15800 Prague, Czech Republic.
Department of Radiology, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, 15006 Prague, Czech Republic.
Exp Ther Med. 2019 May;17(5):4244-4248. doi: 10.3892/etm.2019.7445. Epub 2019 Mar 27.
The present study demonstrates alterations of the contralateral side optic tract to an optic nerve traumatic lesion. Visual acuity of the right eye following Traumatic optic neuropathy (TON) remained at 0 following the injury. Electrophysiological examination using pattern electroretinogram revealed values reduced by 50% in the right eye compared with the left eye. Pattern visual-evoked potential evaluation indicated a bilateral lesion with a higher decrease following right eye stimulation. Magnetic resonance imaging revealed right optic nerve atrophy. Functional magnetic resonance imaging indicated decreased activity of the visual centre during left eye stimulation. The present study revealed contralateral visual tract alterations following unilateral injury, and hypothesize that the ganglion cells of the retina respond initially to glial activation. These changes are, in our view, followed by changes in the visual pathway.
本研究证明了视神经创伤性损伤对侧视束的改变。创伤性视神经病变(TON)后右眼视力在损伤后仍为0。使用图形视网膜电图的电生理检查显示,右眼的值与左眼相比降低了50%。图形视觉诱发电位评估表明存在双侧病变,右眼刺激后下降幅度更大。磁共振成像显示右侧视神经萎缩。功能磁共振成像表明左眼刺激期间视觉中枢的活动减少。本研究揭示了单侧损伤后对侧视觉通路的改变,并推测视网膜神经节细胞最初对胶质细胞激活作出反应。我们认为,这些变化随后会引起视觉通路的改变。