Abdel Maksoud H A, Elharrif Mohamed G, Mahfouz M K, Omnia M A, Abdullah M H, Eltabey M E
Biochemisry Department, Benha University, Egypt.
Basic Medical Sciences Department, Shaqra University, KSA, Saudi Arabia.
Respir Med Case Rep. 2019 Apr 8;27:100836. doi: 10.1016/j.rmcr.2019.100836. eCollection 2019.
inhalation of benzene vapours promote various and dangerous health problems. Fuel station workers are most susceptible to benzene inhalation toxicity. Samples were collected twice, at beginning of the study and 6 months later from 40 fuel station workers from different egyptian governorates and 10 control healthy volunteers. Fuel station workers were sub divided into four groups according to years working in the station. All of them are exposed to benzene vapours and exhausts during their duties, their work shifts were 8 hrs./day. Results indicated that; benzene vapours exposure induced significant increasing in serum Lead and Cadmium and Myeloperoxidase (MPO) enzyme activity levels. This goes with marked immunologic changes presented by decreases in immunoglobulins; IgA and IgG, along with increases in levels of IgM and IgE. Also, Malondialdehyde (MDA) levels were significantly increased. Meanwhile, reduction in some other biochemical parameters including; Copper, Zinc and Iron micronutrients, as well as; Superoxide Dismutase (SOD), Catalase (CAT) enzyme levels and Glutathione (GSH) content. Hence, the study inferred that prolonged benzene inhalation can lead to biochemical and immune disorders, probably through potentiating oxidative stress and inflammation pathways.
吸入苯蒸汽会引发各种危险的健康问题。加油站工作人员最易受到苯吸入毒性的影响。在研究开始时和6个月后，从埃及不同省份的40名加油站工作人员和10名健康对照志愿者中采集了样本。加油站工作人员根据在加油站的工作年限被分为四组。他们所有人在工作期间都接触苯蒸汽和废气，工作班次为每天8小时。结果表明，接触苯蒸汽会导致血清铅、镉和髓过氧化物酶（MPO）酶活性水平显著升高。这伴随着免疫球蛋白的明显变化，即免疫球蛋白A（IgA）和免疫球蛋白G（IgG）降低，同时免疫球蛋白M（IgM）和免疫球蛋白E（IgE）水平升高。此外，丙二醛（MDA）水平显著升高。与此同时，其他一些生化参数降低，包括铜、锌和铁等微量营养素，以及超氧化物歧化酶（SOD）、过氧化氢酶（CAT）酶水平和谷胱甘肽（GSH）含量。因此，该研究推断，长期吸入苯可能通过增强氧化应激和炎症途径导致生化和免疫紊乱。
