Rahimi Sahar, Alaei Hojjatollah, Reisi Parham, Zarrin Bahare, Siahmard Zahra, Pourshanazari Ali Asghar
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2019 Mar 28;8:24. doi: 10.4103/abr.abr_58_16. eCollection 2019.
Spathe of phoenix dactylifera is hard-covering envelope of date palm which is mentioned as a nerve relief in ancient medicine books. In this experiment, three extract doses used in sleeping time, sedative efficacy, and electroencephalography (EEG) protocol to show different aspects of extract effects on sleep.
In three sleeping time, anesthesia time and EEG experiment protocols test group containing three extract doses (62.5, 125, and 250 mg/kg) were compared with saline control group, and in sleeping time experiment control group contained intact, midazolam, and saline group to detail more in behavioral Angel method.
Three extract doses increased sleeping time when compared with saline control group ( < 0.05). In evaluated sedative efficacy, two 125 and 250 mg/kg doses increased anesthesia and showed sedative effect ( < 0.05). In EEG experiment, dose 125 mg/kg increased delta waves and decreased high-frequency waves of alpha and beta. In addition, there were significant decreases in alpha waves of 62.5 and 250 mg/kg doses.
Although all three doses increased sleeping time, dose 125 mg/kg is more efficient for deep and relaxing sleep and suits more for related researches.
海枣的佛焰苞是椰枣树的硬覆盖包被，在古代医学书籍中被提及有舒缓神经的作用。在本实验中，使用三种提取物剂量进行睡眠时间、镇静效果和脑电图（EEG）实验，以展现提取物对睡眠影响的不同方面。
在三个睡眠时间、麻醉时间和脑电图实验方案中，将包含三种提取物剂量（62.5、125和250毫克/千克）的测试组与生理盐水对照组进行比较，在睡眠时间实验中，对照组包含完整组、咪达唑仑组和生理盐水组，以更详细地采用行为学方法进行研究。
与生理盐水对照组相比，三种提取物剂量均增加了睡眠时间（P<0.05）。在评估镇静效果时，125和250毫克/千克这两种剂量增加了麻醉效果并显示出镇静作用（P<0.05）。在脑电图实验中，125毫克/千克剂量增加了δ波，并降低了α波和β波的高频波。此外，62.5和250毫克/千克剂量的α波有显著下降。
虽然所有三种剂量都增加了睡眠时间，但125毫克/千克剂量对深度和放松睡眠更有效，更适合相关研究。
