Sharma Vinay, Adkisson Constance, Gupta Kunal
Hennepin County Medical Center, Minneapolis, MN, USA.
Glob Pediatr Health. 2019 Apr 8;6:2333794X19833711. doi: 10.1177/2333794X19833711. eCollection 2019.
. To reduce neonatal intensive care unit admission rate (NAR) and antibiotic utilization rate (AUR) in ≥36 weeks gestational age infants exposed to maternal chorioamnionitis (MC) through the application of early-onset sepsis calculator (EOSCAL). . This is a single-center cohort study. All infants born ≥36 weeks gestational age and exposed to MC were compared for NAR, AUR, and laboratory evaluation rate (LER) 2 years after and 1 year before the implementation of EOSCAL. . There is a significant decrease in NAR ( < .001), AUR ( < .04), and LER for blood culture, complete blood count, and C-reactive protein ( < .001) after implementation of EOSCAL. If infants received antibiotics, it was for significantly less number of doses ( < .01). There was no increase in the readmission rate. . Use of EOSCAL significantly decreases the rate of NAR, AUR, and LER in infants exposed to MC, without affecting readmission rates and late antibiotic use.
通过应用早发型败血症计算器（EOSCAL），降低孕周≥36周且暴露于母体绒毛膜羊膜炎（MC）的婴儿的新生儿重症监护病房入住率（NAR）和抗生素使用率（AUR）。 这是一项单中心队列研究。将所有孕周≥36周且暴露于MC的婴儿在实施EOSCAL前后1年及2年时的NAR、AUR和实验室评估率（LER）进行比较。 实施EOSCAL后，NAR（<.001）、AUR（<.04）以及血培养、全血细胞计数和C反应蛋白的LER（<.001）均显著降低。如果婴儿接受抗生素治疗，所用剂量显著减少（<.01）。再入院率没有增加。 使用EOSCAL可显著降低暴露于MC的婴儿的NAR、AUR和LER，且不影响再入院率和后期抗生素使用。
