Robinson Tonya, Knott Kimberly, Liu Zhanxu, Kong Maiying, Telang Sucheta
Department of Pediatrics, Division of Neonatology, University of Louisville School of Medicine, Louisville, KY, USA.
Department of Medicine, Division of Medical Oncology, University of Louisville School of Medicine, Louisville, KY, USA.
J Perinatol. 2025 Jan;45(1):104-110. doi: 10.1038/s41372-024-02167-z. Epub 2024 Nov 9.
To determine the impact of the Early Onset Sepsis (EOS) calculator on antibiotic exposure in infants born to mothers with clinical chorioamnionitis and correlate EOS calculator-guided recommendations with placental histopathology.
Retrospective observational study comparing infants ≥ 36 weeks gestation exposed to maternal clinical chorioamnionitis admitted to the neonatal intensive care unit (NICU) before (Group 1, n = 69) and after (Group 2, n = 139) implementation of an EOS calculator protocol for chorioamnionitis. Infant antibiotic exposure and placental pathology were reviewed. Comparisons were made using Mann-Whitney and chi-square tests.
There was a statistically significant decrease in antibiotic exposure from Group 1 to Group 2 (p < 0.001) with no EOS cases missed. No correlation was found between EOS calculator-based treatment and participant placental histopathology (p = 0.966).
Implementation of an EOS calculator protocol specific to our study population reduced antibiotic exposure. No correlations were found between EOS calculator-based antibiotic treatment and histological chorioamnionitis.
确定早发型败血症（EOS）计算器对患有临床绒毛膜羊膜炎的母亲所生婴儿抗生素暴露的影响，并将EOS计算器指导的建议与胎盘组织病理学相关联。
回顾性观察研究，比较孕周≥36周、暴露于母亲临床绒毛膜羊膜炎的新生儿重症监护病房（NICU）入院婴儿，在实施针对绒毛膜羊膜炎的EOS计算器方案之前（第1组，n = 69）和之后（第2组，n = 139）的情况。对婴儿抗生素暴露和胎盘病理学进行了回顾。使用Mann-Whitney检验和卡方检验进行比较。
从第1组到第2组抗生素暴露有统计学显著下降（p < 0.001），且没有漏诊EOS病例。基于EOS计算器的治疗与参与者胎盘组织病理学之间未发现相关性（p = 0.966）。
针对我们研究人群实施的EOS计算器方案减少了抗生素暴露。基于EOS计算器的抗生素治疗与组织学绒毛膜羊膜炎之间未发现相关性。
