Lin Chao-Jin, Li Song-Pei, Deng Sai, Fu Xiao-Mei, Qin Ai-Ping, Yu Xi-Yong
School of Pharmaceutical Sciences of Guangzhou Medical University, Guangdong Key Laboratory of Molecular Target & Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, Guangzhou 511436, China.
Sheng Li Xue Bao. 2019 Apr 25;71(2):205-215.
At present, it is generally believed that the paracrine effect of stem cells in the repair of myocardial injury is one of the important ways for stem cell therapy. Exosomes are phospholipid bilayer-enclosed nanovesicles that secreted by cells under physiological and pathological conditions. Cargo loaded into exosomes including protein, lipids and nucleic acids can be delivered to recipient cells. Therefore, exosomes are recognized as important mediators for intercellular communication. It has been suggested that exosomes from stem cells (eg. embryonic stem cells, induced pluripotent stem cells, cardiac progenitor cells, mesenchymal stem cells and cardiosphere-derived cells) have protective effects against heart injury. In this review, we summarized recent research progresses on stem cell-derived exosomes in myocardial injury, including the therapeutic effects and mechanism.
目前，人们普遍认为干细胞在心肌损伤修复中的旁分泌作用是干细胞治疗的重要途径之一。外泌体是细胞在生理和病理条件下分泌的磷脂双分子层包裹的纳米囊泡。外泌体中装载的货物包括蛋白质、脂质和核酸，可被递送至受体细胞。因此，外泌体被认为是细胞间通讯的重要介质。有研究表明，来自干细胞（如胚胎干细胞、诱导多能干细胞、心脏祖细胞、间充质干细胞和心球衍生细胞）的外泌体对心脏损伤具有保护作用。在本综述中，我们总结了干细胞来源的外泌体在心肌损伤方面的最新研究进展，包括治疗效果和机制。
