维生素D补充剂对多发性硬化症患者临床及亚临床结局的影响：一项系统评价方案
The Effect of Vitamin D Supplements on Clinical and Para-Clinical Outcomes in Patients With Multiple Sclerosis: Protocol for a Systematic Review.
作者信息
Ghajarzadeh Mahsa, Keshtkar Abbas Ali, Azimi Amirreza, Sahraian Mohammad Ali, Mohammadifar Mehdi, Ramagopalan Sreeram V
机构信息
Universal Council of Epidemiology, Universal Scientific Education and Research Network, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
出版信息
JMIR Res Protoc. 2019 Apr 22;8(4):e12045. doi: 10.2196/12045.
BACKGROUND
Multiple sclerosis (MS) is an inflammatory disease, which has a wide range of effects on patients. There are controversies regarding the role of vitamin D in clinical and laboratory improvements in MS patients.
OBJECTIVE
The aim of this systematic review protocol is to evaluate the efficacy of vitamin D supplements on relapse rate, gadolinium-enhancing lesions of magnetic resonance imaging (MRI), and cytokine profiles.
METHODS
We will search PubMed, Scopus, EMBASE, CINAHL, Web of Science, Ovid, ProQuest, American College of Physicians Journal Club database, Health Technology Assessment Database (The Cochrane Collaboration), and National Health System Economic Evaluation Database (The Cochrane Collaboration) and gray literature including reference of included studies and conference abstracts. Clinical trials reporting the effect of any doses of vitamin D on relapse rate, gadolinium-enhancing lesions of MRI, and cytokine profiles will be included. In total, 2 independent researchers will independently assess the studies, extract data, and evaluate the quality of primary studies.
RESULTS
This systematic review was started in September 2017 and the process is continuing. The included articles are evaluated and researchers are going to extract the data.
CONCLUSIONS
To our knowledge, this will be the first comprehensive systematic review aiming to assess the effect of vitamin D supplements on clinical and para-clinical outcomes in patients with multiple sclerosis.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/12045.
背景
多发性硬化症（MS）是一种炎症性疾病，对患者有广泛影响。关于维生素D在MS患者临床和实验室改善中的作用存在争议。
目的
本系统评价方案旨在评估维生素D补充剂对复发率、磁共振成像（MRI）钆增强病灶及细胞因子谱的疗效。
方法
我们将检索PubMed、Scopus、EMBASE、CINAHL、Web of Science、Ovid、ProQuest、美国医师学会杂志俱乐部数据库、卫生技术评估数据库（考克兰协作网）和国家卫生系统经济评估数据库（考克兰协作网）以及灰色文献，包括纳入研究的参考文献和会议摘要。将纳入报告任何剂量维生素D对复发率、MRI钆增强病灶及细胞因子谱影响的临床试验。总共2名独立研究人员将独立评估研究、提取数据并评估原始研究的质量。
结果
本系统评价于2017年9月开始，过程仍在继续。已对纳入文章进行评估，研究人员将提取数据。
结论
据我们所知，这将是第一项旨在评估维生素D补充剂对多发性硬化症患者临床和准临床结局影响的全面系统评价。
国际注册报告识别号（IRRID）：DERR1-10.2196/12045
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