Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Center for Chronic Pain and Drug Abuse, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Pain. 2019 May;160 Suppl 1(Suppl 1):S37-S48. doi: 10.1097/j.pain.0000000000001529.
This review expounds on types and properties of biomarkers for chronic pain, given a mechanistic model of processes underlying development of chronic pain. It covers advances in the field of developing biomarkers for chronic pain, while outlining the general principles of categorizing types of biomarkers driven by specific hypotheses regarding underlying mechanisms. Within this theoretical construct, example biomarkers are described and their properties expounded. We conclude that the field is advancing in important directions and the developed biomarkers have the potential of impacting both the science and the clinical practice regarding chronic pain.
这篇综述阐述了慢性疼痛生物标志物的类型和特性,同时给出了慢性疼痛发展背后的机制模型。它涵盖了慢性疼痛生物标志物开发领域的进展,同时概述了根据潜在机制的具体假设对生物标志物类型进行分类的一般原则。在这个理论框架内,描述了一些示例生物标志物并阐述了它们的特性。我们的结论是,该领域正在朝着重要的方向发展,并且已经开发出的生物标志物有可能对慢性疼痛的科学和临床实践都产生影响。