Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Heidelberg University, Mannheim, Germany.
Pain. 2019 May;160 Suppl 1:S66-S69. doi: 10.1097/j.pain.0000000000001544.
Quantitative sensory testing (QST) is a formal variant of a time-honoured clinical examination technique in neurology, the sensory examination. Prototypical QST profiles have been found in human surrogate models of peripheral sensitization, central sensitization, and deafferentation. Probabilistic sorting of individual patients to any combination of these profiles has been developed, and there is emerging evidence for the predictive value of such sensory profiles for treatment efficacy. This way, QST aids in diagnostics of individual patients and may help guide their care in the future. Deficits in "dynamic" QST have been proposed as predictors of chronic pain (impaired descending inhibition and delayed recovery from central sensitization). Several psychological factors had previously been found to be predictors of pain chronicity (catastrophizing, self-efficacy, and neuroticism). The relative importance of psychological vs sensory testing predictors has not been evaluated. It is likely that both will have differential roles in clinical practice.
定量感觉测试（QST）是神经科久经考验的临床检查技术——感觉检查的一种正式变体。在周围致敏、中枢致敏和去传入的人体替代模型中发现了典型的 QST 特征。已经开发出对个体患者进行这些特征的任何组合的概率分类，并且对于这种感觉特征对治疗效果的预测价值有新的证据。这样，QST 有助于对个体患者进行诊断，并可能有助于指导他们未来的护理。“动态”QST 的缺陷被提出作为慢性疼痛的预测因素（下行抑制受损和中枢致敏的恢复延迟）。以前已经发现几种心理因素是疼痛持续性的预测因素（灾难化、自我效能和神经质）。心理与感觉测试预测因素的相对重要性尚未得到评估。在临床实践中，这两者可能都具有不同的作用。
