Lanzafame R J, Rogers D W, Naim J O, DeFranco C A, Ochej H, Hinshaw J R
Lasers Surg Med. 1986;6(5):439-41. doi: 10.1002/lsm.1900060503.
This study was undertaken to determine the effect of CO2 laser surgery on the incidence of local recurrence following tumor resection. Thirty female Fisher 344 rats were implanted with R3230AC mammary carcinoma. All tumors were completely excised 18-21 days post-implantation. In 15 animals, the resection was done with a scalpel. Fifteen animals underwent laser excision with the Sharplan 733 CO2 laser (TEMoo, 125 mm handpiece, 25W continuous wave). Primary tumor size was 17.6 +/- 1.4 mm in the scalpel group and 21.2 +/- 6.3 mm in the laser group. Tumor recurred in 14/15 (93.4%) of the scalpel group and 5/15 (33.3%) of the laser group (p less than 0.001). The site of recurrence was incisional in 13/15 (86.7%) of the scalpel group and 3/15 (20%) of the laser group (p less than 0.001). Axillary metastases occurred in 2/15 (13.3%) in each group. The disease-free interval was 26 days in the laser group and 12 days in the scalpel group. The CO2 laser is an effective surgical adjunct to reduce local tumor seeding and recurrence.
本研究旨在确定二氧化碳激光手术对肿瘤切除后局部复发率的影响。30只雌性Fisher 344大鼠植入R3230AC乳腺癌。所有肿瘤在植入后18 - 21天被完全切除。15只动物用手术刀进行切除。15只动物用Sharplan 733二氧化碳激光（TEMoo，125mm手持件，25W连续波）进行激光切除。手术刀组原发肿瘤大小为17.6±1.4mm，激光组为21.2±6.3mm。手术刀组14/15（93.4%）出现肿瘤复发，激光组5/15（33.3%）出现肿瘤复发（p＜0.001）。手术刀组13/15（86.7%）的复发部位在切口处，激光组3/15（20%）的复发部位在切口处（p＜0.001）。每组各有2/15（13.3%）出现腋窝转移。激光组无病生存期为26天，手术刀组为12天。二氧化碳激光是一种有效的手术辅助手段，可减少局部肿瘤种植和复发。
