Paczuska J, Świtalska M, Nowak M, Kiełbowicz Z
Department of Surgery, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wrocław, Poland.
Vet Comp Oncol. 2018 Mar;16(1):47-54. doi: 10.1111/vco.12310. Epub 2017 Mar 28.
The important goal of modern research in the field of surgical oncology is the quest for a tool that could improve the outcomes of tumour excision.
The aim of this study was to compare the usefulness of the CO laser with flexible hollow waveguide and scalpel in mammary tumour excision.
MATERIALS & METHODS: A total of 112 female BALB/c mice with implanted orthotopically 4T1-luc2-tdTomato tumour cells were included in the research. Tumours were excised in 48 mice using the CO laser and in 48 through scalpel surgery. The control group consisted of 16 untreated mice. The evaluation of surgical outcome was obtained by in vivo bioluminescence and fluorescence imaging and post-mortem histopathological examination.
There were no significant differences between recurrence rates, metastases and survival time in groups excised with the scalpel and CO laser.
The CO laser has similar efficacy compared with conventional scalpel excision for local recurrence rates, incidence of distant metastases and survival time and can be safely applied in oncological surgery.
外科肿瘤学领域现代研究的重要目标是寻求一种能够改善肿瘤切除效果的工具。
本研究的目的是比较CO激光联合柔性空心波导与手术刀在乳腺肿瘤切除中的实用性。
共有112只原位植入4T1-luc2-tdTomato肿瘤细胞的雌性BALB/c小鼠纳入研究。48只小鼠使用CO激光切除肿瘤，48只通过手术刀手术切除肿瘤。对照组由16只未治疗的小鼠组成。通过体内生物发光和荧光成像以及死后组织病理学检查对手术结果进行评估。
手术刀组和CO激光组在复发率、转移情况和生存时间方面无显著差异。
与传统手术刀切除相比，CO激光在局部复发率、远处转移发生率和生存时间方面具有相似的疗效，可安全应用于肿瘤外科手术。
