• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

前列腺干细胞抗原变异rs2294008对膀胱癌风险的影响。

Contribution of prostate stem cell antigen variation rs2294008 to the risk of bladder cancer.

作者信息

Deng Shi, Ren Zheng Ju, Jin Tao, Yang Bo, Dong Qiang

机构信息

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, P.R. China.

出版信息

Medicine (Baltimore). 2019 Apr;98(16):e15179. doi: 10.1097/MD.0000000000015179.

DOI:10.1097/MD.0000000000015179
PMID:31008939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6494373/
Abstract

OBJECTIVE

Number of studies have been performed to evaluate the relationship between prostate stem cell antigen (PSCA) variation rs2294008 and bladder cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conducted to comprehensively evaluate the overall association.

METHODS

Pubmed, Web of science, Embase, China biology medical literature database (CBM), China National Knowledge Infrastructure (CNKI), Wan Fang and Weipu databases were searched before June 30, 2018. The strength of associations was assessed using odds ratios (ORs) and 95% confidence intervals (CIs). All of the statistical analyses were conducted using Review Manager 5.3 and Stata 14.0.

RESULTS

Ten studies involved 14,021 cases and 26,871 controls. Overall, significant association was observed between the PSCA gene variant rs2294008 polymorphism and bladder cancer (T vs C: OR = 1.16, 95%CI = 1.12-1.20; TT vs CC: OR = 1.32, 95%CI = 1.24-1.41; TT vs CT+CC: OR = 1.15, 95%CI = 1.09-1.22; TT+CT vs CC: OR = 1.27, 95%CI = 1.21-1.34). In subgroup analysis by ethnic group, a statistically significant association was observed in Asians (T vs C: OR = 1.23, 95%CI = 1.15-1.31) and Caucasians (T vs C: OR = 1.14, 95%CI = 1.10-1.18). The sensitivity analysis confirmed the reliability and stability of the meta-analysis.

CONCLUSION

Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer.

摘要

目的

已有多项研究评估前列腺干细胞抗原（PSCA）基因变异rs2294008与膀胱癌风险之间的关系，但样本量较小且结果相互矛盾。本荟萃分析旨在全面评估总体关联。

方法

检索了截至2018年6月30日的PubMed、Web of science、Embase、中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方和维普数据库。采用比值比（OR）和95%置信区间（CI）评估关联强度。所有统计分析均使用Review Manager 5.3和Stata 14.0进行。

结果

10项研究纳入了14021例病例和26871例对照。总体而言，观察到PSCA基因变异rs2294008多态性与膀胱癌之间存在显著关联（T与C相比：OR = 1.16，95%CI = 1.12 - 1.20；TT与CC相比：OR = 1.32，95%CI = 1.24 - 1.41；TT与CT + CC相比：OR = 1.15，95%CI = 1.09 - 1.22；TT + CT与CC相比：OR = 1.27，95%CI = 1.21 - 1.34）。在按种族分组的亚组分析中，在亚洲人（T与C相比：OR = 1.23，95%CI = 1.15 - 1.31）和高加索人（T与C相比：OR = 1.14，95%CI = 1.10 - 1.18）中观察到统计学显著关联。敏感性分析证实了荟萃分析的可靠性和稳定性。

结论

我们的荟萃分析支持PSCA基因变异rs2294008多态性可能导致个体对膀胱癌的易感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/be81290a596e/medi-98-e15179-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/1e98de7b5595/medi-98-e15179-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/88685839e556/medi-98-e15179-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/79003ea68dc3/medi-98-e15179-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/1c30da08ea1f/medi-98-e15179-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/aabe2f4e7fef/medi-98-e15179-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/5c7060e48dcd/medi-98-e15179-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/be81290a596e/medi-98-e15179-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/1e98de7b5595/medi-98-e15179-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/88685839e556/medi-98-e15179-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/79003ea68dc3/medi-98-e15179-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/1c30da08ea1f/medi-98-e15179-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/aabe2f4e7fef/medi-98-e15179-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/5c7060e48dcd/medi-98-e15179-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7a/6494373/be81290a596e/medi-98-e15179-g010.jpg

相似文献

1
Contribution of prostate stem cell antigen variation rs2294008 to the risk of bladder cancer.前列腺干细胞抗原变异rs2294008对膀胱癌风险的影响。
Medicine (Baltimore). 2019 Apr;98(16):e15179. doi: 10.1097/MD.0000000000015179.
2
The rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis.rs2294008（C/T）多态性增加胃癌和膀胱癌风险：一项荟萃分析。
Genet Test Mol Biomarkers. 2023 Feb;27(2):44-55. doi: 10.1089/gtmb.2022.0067.
3
Prostate stem cell antigen rs2294008 (C>T) polymorphism and bladder cancer risk: a meta-analysis based on cases and controls.前列腺干细胞抗原rs2294008（C>T）多态性与膀胱癌风险：一项基于病例对照的荟萃分析。
Genet Mol Res. 2014 Jul 25;13(3):5534-40. doi: 10.4238/2014.July.25.7.
4
The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis.基于全基因组关联研究的 PSCA 多态性与胃癌风险相关：一项荟萃分析。
J Cancer Res Clin Oncol. 2012 Aug;138(8):1339-45. doi: 10.1007/s00432-012-1210-6. Epub 2012 Apr 6.
5
PSCA rs2294008 Polymorphism with Increased Risk of Cancer.PSCA基因rs2294008多态性与癌症风险增加相关
PLoS One. 2015 Aug 26;10(8):e0136269. doi: 10.1371/journal.pone.0136269. eCollection 2015.
6
Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population.PSCA 基因多态性与中国人群膀胱癌易感性的关系。
Carcinogenesis. 2010 Apr;31(4):621-4. doi: 10.1093/carcin/bgp323. Epub 2010 Jan 18.
7
Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk.PSCA 基因中的常见遗传变异影响基因表达和膀胱癌风险。
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4974-9. doi: 10.1073/pnas.1202189109. Epub 2012 Mar 13.
8
CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis.细胞毒性T淋巴细胞相关蛋白4基因rs5742909多态性与宫颈癌风险：一项荟萃分析。
Medicine (Baltimore). 2020 Mar;99(11):e19433. doi: 10.1097/MD.0000000000019433.
9
Genetic variation in PSCA is associated with bladder cancer susceptibility in a Korean population.前列腺干细胞抗原（PSCA）的基因变异与韩国人群的膀胱癌易感性相关。
Asian Pac J Cancer Prev. 2014;15(20):8901-4. doi: 10.7314/apjcp.2014.15.20.8901.
10
PSCA rs2294008 C > T polymorphism contributes to gastric and bladder cancer risk.前列腺干细胞抗原基因（PSCA）rs2294008位点的C>T多态性与胃癌和膀胱癌风险相关。
Ther Clin Risk Manag. 2015 Feb 13;11:237-45. doi: 10.2147/TCRM.S77089. eCollection 2015.

引用本文的文献

1
Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer.多组学汇总数据的整合分析鉴定出膀胱癌新的血浆蛋白生物标志物和药物靶点。
Discov Oncol. 2025 May 2;16(1):660. doi: 10.1007/s12672-025-02476-5.
2
Significance of PSCA as a novel prognostic marker and therapeutic target for cancer.前列腺干细胞抗原作为一种新型癌症预后标志物和治疗靶点的意义。
Cancer Cell Int. 2024 Apr 16;24(1):135. doi: 10.1186/s12935-024-03320-6.
3
Genetic Polymorphisms Involved in Bladder Cancer: A Global Review.

本文引用的文献

1
Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma.前列腺干细胞抗原基因表达与口腔鳞状细胞癌之间的相关性
Oncol Lett. 2018 Jun;15(6):9151-9161. doi: 10.3892/ol.2018.8468. Epub 2018 Apr 11.
2
Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population.中国人群中PSCA基因的单核苷酸多态性与乳腺癌风险
Oncotarget. 2016 May 10;7(19):27665-75. doi: 10.18632/oncotarget.8491.
3
Cancer statistics, 2016.癌症统计数据，2016 年。
膀胱癌相关的基因多态性：一项全球综述。
Oncol Rev. 2023 Nov 6;17:10603. doi: 10.3389/or.2023.10603. eCollection 2023.
4
Bladder cancer course, four genetic high-risk variants, and histopathological findings.膀胱癌病程、四种遗传高危变异及组织病理学发现。
EXCLI J. 2023 Aug 18;22:867-879. doi: 10.17179/excli2023-5862. eCollection 2023.
5
Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology.填补膀胱癌后第二原发恶性肿瘤研究中的空白：关注种族和组织学。
Front Public Health. 2022 Nov 17;10:1036722. doi: 10.3389/fpubh.2022.1036722. eCollection 2022.
6
State-of-the-Art Advances of Nanomedicine for Diagnosis and Treatment of Bladder Cancer.膀胱癌诊断与治疗的纳米医学最新进展
Biosensors (Basel). 2022 Sep 27;12(10):796. doi: 10.3390/bios12100796.
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. doi: 10.3322/caac.21332. Epub 2016 Jan 7.
4
PSCA rs2294008 Polymorphism with Increased Risk of Cancer.PSCA基因rs2294008多态性与癌症风险增加相关
PLoS One. 2015 Aug 26;10(8):e0136269. doi: 10.1371/journal.pone.0136269. eCollection 2015.
5
Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease.PSCA rs2294008基因变异与胃癌预后不良、易感性增加及十二指肠溃疡疾病风险降低的关联。
Int J Cancer. 2015 Sep 15;137(6):1362-73. doi: 10.1002/ijc.29500. Epub 2015 Mar 19.
6
Association between PSCA mRNA expression levels and rs2294008 polymorphism in transitional cell cancer of the bladder.膀胱移行细胞癌中PSCA mRNA表达水平与rs2294008多态性之间的关联。
Oncol Lett. 2015 Feb;9(2):557-562. doi: 10.3892/ol.2014.2734. Epub 2014 Nov 24.
7
PSCA and MUC1 gene polymorphisms are associated with gastric cancer and pre-malignant gastric conditions [corrected].PSCA 和 MUC1 基因多态性与胃癌及癌前胃部病变相关 [已更正]。
Anticancer Res. 2014 Dec;34(12):7167-75.
8
Genetic variation in PSCA is associated with bladder cancer susceptibility in a Korean population.前列腺干细胞抗原（PSCA）的基因变异与韩国人群的膀胱癌易感性相关。
Asian Pac J Cancer Prev. 2014;15(20):8901-4. doi: 10.7314/apjcp.2014.15.20.8901.
9
Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.全基因组关联研究在日本人群中确定了15号染色体长臂24区上与膀胱癌风险相关的单核苷酸多态性。
Hum Mol Genet. 2015 Feb 15;24(4):1177-84. doi: 10.1093/hmg/ddu512. Epub 2014 Oct 3.
10
Prostate stem cell antigen rs2294008 (C>T) polymorphism and bladder cancer risk: a meta-analysis based on cases and controls.前列腺干细胞抗原rs2294008（C>T）多态性与膀胱癌风险：一项基于病例对照的荟萃分析。
Genet Mol Res. 2014 Jul 25;13(3):5534-40. doi: 10.4238/2014.July.25.7.