Huang Zhonglian, Zhao Jingjing, Ding Ke, Lv Yue, Zhang Congjun, Chao Herta H, Li Chiang-Shan, Cheng Huaidong
Department of Oncology, The Second Affiliated Hospital of Anhui Medical University.
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui.
Medicine (Baltimore). 2019 Apr;98(16):e15301. doi: 10.1097/MD.0000000000015301.
To investigate the relationship between depression and the self-reported prospective memory (SPM) problems in breast cancer survivors who have received chemotherapy.Sixty-three breast cancer patients were administered with self-rating depression scale (SDS) and the prospective memory questionnaire as part of extensive neuropsychological assessments before and after chemotherapy. The performance of SDS and SPM were compared, with the level of significance set at P < .05.Compared with the group before chemotherapy, there is a significant difference on the SPM score (t = 6.069, P = .000) in breast cancer patients after chemotherapy. Further, there is also a significant difference on the SPM score (t = -4.348, P = .000) between the patients with and without depression group after chemotherapy.The present result indicated that the depression in breast cancer survivors after chemotherapy may be involved in their chemotherapy-induced SPM impairment.
探讨接受化疗的乳腺癌幸存者中抑郁与自我报告的前瞻性记忆（SPM）问题之间的关系。对63例乳腺癌患者在化疗前后进行了广泛的神经心理学评估，包括使用自评抑郁量表（SDS）和前瞻性记忆问卷。比较SDS和SPM的表现，显著性水平设定为P<0.05。与化疗前组相比，化疗后乳腺癌患者的SPM得分有显著差异（t=6.069，P=0.000）。此外，化疗后有抑郁组和无抑郁组患者的SPM得分也有显著差异（t=-4.348，P=0.000）。目前的结果表明，化疗后乳腺癌幸存者的抑郁可能与化疗引起的SPM损害有关。
