Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation - Education City, Doha, Qatar.
Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
Sci Rep. 2019 Feb 4;9(1):1136. doi: 10.1038/s41598-018-37833-8.
This study aimed at characterizing herpes simplex virus type 1 (HSV-1) epidemiology in the Middle East and North Africa (MENA). HSV-1 records were systematically reviewed. Findings were reported following the PRISMA guidelines. Random-effects meta-analyses were implemented to estimate pooled mean HSV-1 seroprevalence. Random-effects meta-regressions were conducted to identify predictors of higher seroprevalence. Thirty-nine overall seroprevalence measures yielding 85 stratified measures were identified and included in the analyses. Pooled mean seroprevalence was 65.2% (95% CI: 53.6-76.1%) in children, and 91.5% (95% CI: 89.4-93.5%) in adults. By age group, seroprevalence was lowest at 60.5% (95% CI: 48.1-72.3%) in <10 years old, followed by 85.6% (95% CI: 80.5-90.1%) in 10-19 years old, 90.7% (95% CI: 84.7-95.5%) in 20-29 years old, and 94.3% (95% CI: 89.5-97.9%) in ≥30 years old. Age was the strongest predictor of seroprevalence explaining 44.3% of the variation. Assay type, sex, population type, year of data collection, year of publication, sample size, and sampling method were not significantly associated with seroprevalence. The a priori considered factors explained 48.6% of the variation in seroprevalence. HSV-1 seroprevalence persists at high levels in MENA with most infections acquired in childhood. There is no evidence for declines in seroprevalence despite improving socio-economic conditions.
本研究旨在描述中东和北非（MENA）地区单纯疱疹病毒 1 型（HSV-1）的流行病学特征。我们系统地回顾了 HSV-1 的相关记录，并按照 PRISMA 指南报告了研究结果。我们实施了随机效应荟萃分析来估计 HSV-1 血清阳性率的汇总均值，同时进行了随机效应荟萃回归来确定更高血清阳性率的预测因素。我们确定并纳入了 39 项总体血清阳性率测量结果和 85 项分层测量结果进行分析。儿童的 HSV-1 血清阳性率汇总均值为 65.2%（95%CI：53.6-76.1%），成人的 HSV-1 血清阳性率汇总均值为 91.5%（95%CI：89.4-93.5%）。按年龄分组，血清阳性率在<10 岁的人群中最低，为 60.5%（95%CI：48.1-72.3%），10-19 岁的人群中为 85.6%（95%CI：80.5-90.1%），20-29 岁的人群中为 90.7%（95%CI：84.7-95.5%），≥30 岁的人群中为 94.3%（95%CI：89.5-97.9%）。年龄是血清阳性率的最强预测因素，可解释 44.3%的变异。检测类型、性别、人群类型、数据收集年份、发表年份、样本量和采样方法与血清阳性率均无显著相关性。预先考虑的因素可解释血清阳性率 48.6%的变异。HSV-1 血清阳性率在 MENA 地区持续处于较高水平，且大多数感染发生在儿童时期。尽管社会经济条件有所改善，但没有证据表明血清阳性率下降。
