Department of Medical Microbiology, Capital Medical University, Beijing, China.
Center for Disease Prevention and Control, Chaoyang District, Beijing, China.
J Infect. 2019 Jul;79(1):1-6. doi: 10.1016/j.jinf.2019.04.011. Epub 2019 Apr 19.
This study was aimed to determine pertussis specific serum PT-IgG antibodies in healthy individuals during 2010 and 2015/2016 in Beijing, China.
A total of 3884 healthy individuals were included: 3058 aged 3-69 years randomly selected from an epidemiological survey conducted in 2010, and 826 aged 20-39 years selected from those who attended an annual medical examination in 2015/2016. Serum PT-IgG antibodies were determined using the Serion/Virion ELISA kits.
Of 3058 subjects in 2010, 167 (5.5%) and 39 (1.3%) subjects had PT-IgG antibodies ≥40 IU/ml and ≥100 IU/ml, respectively. No differences were observed among different age groups. Altogether, 26.2% had undetectable PT-IgG antibodies (<5 IU/ml), and the highest undetectable rate of 56.8% was found in children aged 3-5 years. When the age group of 20-39 years was compared between the two periods, no difference was found in seroprevalence of PT-IgG antibodies ≥ 40 IU/ml (5.1% vs. 4.0%). However, an undetectable rate of PT-IgG antibodies was significantly higher in 2015/2016 than that in 2010 (57.4% vs. 29.1%, p < 0.001).
Our results showed that about 5% of individuals had PT-IgG antibodies indicative of a recent infection, and adults at childbearing age have an increased risk to pertussis in China.
本研究旨在测定 2010 年和 2015/2016 年期间中国北京健康人群中的百日咳特异性血清 PT-IgG 抗体。
共纳入 3884 名健康个体：2010 年进行的一项流行病学调查中随机选择的 3058 名年龄为 3-69 岁的个体，以及 2015/2016 年参加年度体检的 826 名年龄为 20-39 岁的个体。使用 Serion/Virion ELISA 试剂盒测定血清 PT-IgG 抗体。
2010 年的 3058 名受试者中，167 名（5.5%）和 39 名（1.3%）受试者的 PT-IgG 抗体≥40 IU/ml 和≥100 IU/ml，分别。不同年龄组之间无差异。共有 26.2%的个体 PT-IgG 抗体不可检测（<5 IU/ml），其中年龄在 3-5 岁的儿童不可检测率最高，为 56.8%。当比较两个时期的 20-39 岁年龄组时，PT-IgG 抗体≥40 IU/ml 的血清阳性率（5.1%比 4.0%）无差异。然而，2015/2016 年 PT-IgG 抗体不可检测率明显高于 2010 年（57.4%比 29.1%，p<0.001）。
我们的结果表明，约 5%的个体具有近期感染的 PT-IgG 抗体，育龄期成人在中国患百日咳的风险增加。
