Shi Wei, Wang Bingsong, Meng Qinghong, Zhang Xianlai, Li Zhen, He Fang, Ying Fei, Cong Linyan, Yao Kaihu
MOE Key Laboratory of Major Diseases in Children，National Key Discipline of Pediatrics, National Clinical Research Center for Respiratory Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
Pediatric Respiratory Department, The First People's Hospital of Wuhu, Wuhu, China.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2318892. doi: 10.1080/21645515.2024.2318892. Epub 2024 Mar 11.
This study aimed to elucidate the seroprevalence of antibodies to tetanus and pertussis among Chinese health care workers. Blood specimens from health care workers were collected during the 2021 annual medical examination at the First People's Hospital of Wuhu. Commercial ELISA kits were employed to quantify serum IgG antibodies against tetanus toxin (anti-TT IgG) and both IgG and IgA antibodies against pertussis toxin (anti-PT IgG, anti-PT IgA). A concentration of anti-TT IgG exceeding 0.1 IU/ml was deemed seroprotective against tetanus, while concentrations of anti-PT IgG ≥ 50 IU/ml or anti-PT IgA ≥ 15 IU/ml were indicative of a prior pertussis infection. The overall seroprotective rate for anti-TT IgG stood at 10.43% (92/882), with the highest seroprotective rate (13.91%) in the 20-29 age group, followed by the 30-39 age group (10.57%), 40-49 age group (5.80%), and 50-59 age group (5.63%). Eighteen (2.04%) of the studied subjects were positive to anti-PT IgG, and the positive rate in 20-39 age group and 40-59 age group was 1.19% (8/673) and 4.78% (10/209), respectively. Thirty (3.40%) subjects displayed anti-PT IgG levels ≥100 IU/ml and/or anti-PT IgA ≥ 15 IU/ml, suggesting a recent pertussis infection within the preceding year. Over half (503/882, 57.03%) had undetectable anti-PT IgG antibodies. The majority of health care workers in China appear susceptible to tetanus and pertussis, and a significant subset has experienced pertussis infection. The implementation of booster vaccinations against these diseases for Chinese health care workers is recommended.
本研究旨在阐明中国医护人员中破伤风和百日咳抗体的血清流行率。在芜湖市第一人民医院2021年度体检期间收集医护人员的血液标本。使用商用ELISA试剂盒定量检测抗破伤风毒素血清IgG抗体（抗TT IgG）以及抗百日咳毒素的IgG和IgA抗体（抗PT IgG、抗PT IgA）。抗TT IgG浓度超过0.1 IU/ml被视为对破伤风具有血清保护作用，而抗PT IgG≥50 IU/ml或抗PT IgA≥15 IU/ml的浓度表明既往感染过百日咳。抗TT IgG的总体血清保护率为10.43%（92/882），其中20 - 29岁年龄组的血清保护率最高（13.91%），其次是30 - 39岁年龄组（10.57%）、40 - 49岁年龄组（5.80%）和50 - 59岁年龄组（5.63%）。18名（2.04%）研究对象抗PT IgG呈阳性，20 - 39岁年龄组和40 - 59岁年龄组的阳性率分别为1.19%（8/673）和4.78%（10/209）。30名（3.40%）受试者的抗PT IgG水平≥100 IU/ml和/或抗PT IgA≥15 IU/ml，表明在前一年近期感染过百日咳。超过一半（50 /882，57.03%）的人抗PT IgG抗体检测不到。中国大多数医护人员似乎对破伤风和百日咳易感，且有相当一部分人曾感染过百日咳。建议对中国医护人员实施这些疾病的加强免疫接种。
