Department of Immunization Program, Shaanxi Provincial Center for Disease Control and Prevention, Xi'an, Shaanxi, China.
Hum Vaccin Immunother. 2022 Nov 30;18(6):2133913. doi: 10.1080/21645515.2022.2133913. Epub 2022 Oct 18.
To determine the estimated pertussis incidence in adults and the need for a booster dose by detecting pertussis and diphtheria antibody levels in adults in Shaanxi province, China. Blood samples were collected from healthy individuals aged 18-59 years in Shaanxi province in 2017. Serum immunoglobulin G (IgG) antibodies against pertussis toxin (PT) and diphtheria toxin (DT) were determined using enzyme-linked immunosorbent assay. The data on reported pertussis cases in Shaanxi province were collected from the China Information System for Disease Control and Prevention and compared with the results of this study. A total of 4307 subjects were enrolled. The mean concentration of anti-PT IgG was 19.6 IU/mL (95% CI = 18.9-20.3), and the positive rate (≥40 IU/mL) was 11.0% (474/4307), of which recent infections (≥100 IU/mL) accounted for 1.2% (53/4307). Only one adult case of pertussis was reported in 2017, which is much lower than the results of this study. The mean concentration of anti-DT IgG was 0.04 IU/mL (95% CI = 0.04-0.05), and the positive rate (≥0.01 IU/mL) was 82.3% (3543/4307). The mean concentration of anti-DT IgG decreased from 0.07 IU/mL in the 18-29 year-old group to 0.03 IU/mL in the 50-59 year-old-group, and the positivity rate decreased from 86.7% to 78.7%. Our study suggests that pertussis is not uncommon among adults. The existing surveillance system might have underestimated the true incidence of pertussis. The diphtheria antibody levels decreased with age. Booster vaccination against pertussis should be considered for adolescents and young adults.
为了确定陕西省成年人百日咳的估计发病率和是否需要加强剂量，我们检测了陕西省 18-59 岁健康成年人的百日咳和白喉抗体水平。2017 年采集了陕西省 18-59 岁健康人群的血样。采用酶联免疫吸附试验检测血清中针对百日咳毒素（PT）和白喉毒素（DT）的免疫球蛋白 G（IgG）抗体。陕西省百日咳报告病例数据来源于中国疾病预防控制信息系统，并与本研究结果进行了比较。共纳入 4307 例受试者。抗-PT IgG 的平均浓度为 19.6 IU/mL（95%可信区间=18.9-20.3），阳性率（≥40 IU/mL）为 11.0%（474/4307），其中近期感染（≥100 IU/mL）占 1.2%（53/4307）。2017 年仅报告了 1 例成人百日咳病例，远低于本研究结果。抗-DT IgG 的平均浓度为 0.04 IU/mL（95%可信区间=0.04-0.05），阳性率（≥0.01 IU/mL）为 82.3%（3543/4307）。抗-DT IgG 浓度从 18-29 岁组的 0.07 IU/mL 降至 50-59 岁组的 0.03 IU/mL，阳性率从 86.7%降至 78.7%。本研究表明，成人百日咳并不少见。现有的监测系统可能低估了百日咳的真实发病率。白喉抗体水平随年龄下降。应考虑为青少年和年轻成人接种百日咳加强疫苗。
