Jin Xiufeng, Xu Shangdong, Chen Zengsheng, Zhang Xiwen, Huang Lianjun, Sun Lizhong
Department of Cardiology Ward 1, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.
School of Aerospace Engineering, Tsinghua University, Beijing, China.
Ann Vasc Surg. 2019 Aug;59:237-243. doi: 10.1016/j.avsg.2019.01.012. Epub 2019 Apr 19.
The objective of the study was to investigate the hemodynamic changes of the blood flow in the aneurysm model after the multilayer stent placement using the fluid dynamic method, to analyze the effectiveness and properties of the multilayer stent in the treatment of aortic aneurysms.
A water tank was filled with 5 L of experimental liquid after the circular flow pressure test platform with a glass aneurysm model, and a multilayer stent was built. Pressure at the middle part and the distal aneurysm neck part of the model was then measured. At each site, the pressure was measured 20 times at 1-min intervals, and the testing results were averaged for accuracy.
Without the stent, mean pressure at the middle part and at the distal aneurysm neck part of the model was 11.19 ± 0.23 Kpa and 13.31 ± 0.28 Kpa, respectively. With the stent, the mean pressure decreased to 10.60 ± 0.27 Kpa and 12.60 ± 0.29 Kpa, and the average difference was 0.59 ± 0.15 Kpa and 0.71 ± 0.15 Kpa, respectively.
After the placement of the multilayer stent, pressure inside the model at the middle part and distal neck part could both be diminished, yet the mean dropped pressure may be too small to be sufficient to cause significant impact on preventing the expansion of abdominal aortic aneurysm; therefore, the pressure-lowering effect of the multilayer stent for abdominal aortic aneurysm may not be ideal compared with the traditional covered stents.
本研究的目的是使用流体动力学方法研究多层支架置入动脉瘤模型后血流的血流动力学变化，分析多层支架治疗主动脉瘤的有效性和特性。
在带有玻璃动脉瘤模型的循环流压力测试平台后，向水箱中注入5升实验液体，并构建多层支架。然后测量模型中部和远端动脉瘤颈部的压力。在每个部位，每隔1分钟测量压力20次，并对测试结果求平均值以提高准确性。
无支架时，模型中部和远端动脉瘤颈部的平均压力分别为11.19±0.23千帕和13.31±0.28千帕。有支架时，平均压力降至10.60±0.27千帕和12.60±0.29千帕，平均差值分别为0.59±0.15千帕和0.71±0.15千帕。
多层支架置入后，模型中部和远端颈部的压力均可降低，但平均降压幅度可能过小，不足以对预防腹主动脉瘤扩张产生显著影响；因此，与传统覆膜支架相比，多层支架对腹主动脉瘤的降压效果可能不理想。
