使用气体交换模拟系统比较不同的逐口气体交换算法。
Comparison of different breath-by-breath gas exchange algorithms using a gas exchange simulation system.
机构信息
Department of Medicine, University of Udine, p.le Kolbe 4, Udine, Italy.
Institute of Physiology and Anatomy, German Sport University Cologne, Am Sportpark Müngersdorf 6, Cologne, Germany.
出版信息
Respir Physiol Neurobiol. 2019 Aug;266:171-178. doi: 10.1016/j.resp.2019.04.009. Epub 2019 Apr 19.
BACKGROUND
Mechanical Gas Exchange Simulation Systems (GESS) have never been used to compare different breath-by-breath oxygen uptake calculation algorithms.
METHODS
Oxygen uptakes were calculated for each GESS cycle by the "Expiration-only" algorithm (estimating inspiratory volume from the expiratory one), and by two "alveolar" algorithms (both processing inspiratory and expiratory flows and designed to account for the changes in lung gas stores). The volume of oxygen stored in the GESS from one cycle to the subsequent one was either maintained constant or increased/decreased by changing the pumped gas volumes.
RESULTS
Overlapping oxygen uptakes were obtained maintaining constant the volume of oxygen stored (grand average: 0.420 ± 0.019 L/min, p = ns). The "Expiration-only" algorithm overestimated the decreases of the stored oxygen by 34%, whereas the "alveolar" algorithms underestimated the increases by 25%; in the other conditions, the changes of the stored oxygen were appropriately accounted for.
CONCLUSIONS
The use of "alveolar" algorithms is recommended, particularly so when abrupt changes in the stored oxygen volume occur.
背景
机械气体交换模拟系统（GESS）从未被用于比较不同的逐口气氧摄取计算算法。
方法
通过“仅呼气”算法（从呼气中估计吸气量）和两种“肺泡”算法（均处理吸气和呼气流量，并旨在考虑肺气体储存的变化）为每个 GESS 循环计算氧摄取量。从一个循环到下一个循环，GESS 中储存的氧气量要么通过改变泵送气体量保持恒定，要么增加/减少。
结果
通过保持氧气储存量恒定（总体平均值：0.420±0.019 L/min，p=ns）获得重叠的氧摄取量。“仅呼气”算法高估了储存氧气的减少量，为 34%，而“肺泡”算法低估了增加量，为 25%；在其他情况下，储存氧气的变化得到了适当的考虑。
结论
建议使用“肺泡”算法，特别是当储存氧气量发生急剧变化时。
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