Saul G, Rose H, Kehrberg G
Onkologie. 1986 Oct;9(5):257-61. doi: 10.1159/000216024.
In our investigations the qualification of the substances 2-cyanoethyl urea, thymus extract and lithium carbonate was tested for a potential reducing or shortening of the leukocyte-depression in rats after whole-body irradiation. Intravenous applications of 2-cyanoethyl urea and intramuscular injections of thymus extract showed no effect in Wistar rats not only in increase of leukocyte number of peripheral blood, but also in variation of leukocyte portion in differential blood-count. Leukocytes depression appearing in consequence of whole-body irradiation was independent of cyanoethyl urea applications and of thymus extract, too. Lithium carbonate shows a significant increase of leukocytes in peripheral blood in dependence of dosage and frequency of applications. After whole-body irradiation with 7 Gy under lithium therapy, it was shown that on day 6 after irradiation leukocyte number was significantly higher than in controls. Radiogenic leukopenia phase was reduced significantly by lithium.
在我们的研究中，对2-氰基乙基脲、胸腺提取物和碳酸锂这几种物质进行了测试，以探究它们是否有可能减轻或缩短大鼠全身照射后的白细胞减少期。静脉注射2-氰基乙基脲和肌肉注射胸腺提取物对Wistar大鼠外周血白细胞数量的增加以及白细胞分类计数中白细胞比例的变化均无影响。全身照射导致的白细胞减少与氰基乙基脲的应用以及胸腺提取物也无关。碳酸锂可使外周血白细胞数量随用药剂量和频率的增加而显著升高。在7 Gy全身照射后进行锂治疗，结果显示照射后第6天白细胞数量显著高于对照组。锂显著缩短了放射性白细胞减少期。
