Jones T C, Alkan S, Erb P
Parasite Immunol. 1986 Nov;8(6):619-29. doi: 10.1111/j.1365-3024.1986.tb00875.x.
An animal model for the study of transient lymphadenopathy-splenomegaly during toxoplasmosis is presented. Injection of CBA/J mice with the low virulent, cyst-forming strain of Toxoplasma gondii (Pe strain) induces a three to four fold increase in weight and cellularity of spleen and lymph nodes with peak changes at 30-50 days after infection. The spleen displays marked haemopoiesis, a 30 fold increase in mononuclear phagocytes, and a two fold increase in Lyt2+ lymphocytes. Lymph nodes show a five fold increase in mononuclear phagocytes and a four and a half fold increase in Lyt2+ T cells. The increase in mononuclear phagocytes significantly alters T cell/macrophage ratios and this is associated with decreases in in vitro cell proliferation to mitogen and toxoplasma antigen. The relationship between alterations in cell balance of mononuclear phagocytes and T cell subsets and the expression of transient immune dysfunction can now be examined by modulating changes in these cell types.
本文介绍了一种用于研究弓形虫病期间短暂性淋巴结病-脾肿大的动物模型。给CBA/J小鼠注射低毒力、形成包囊的弓形虫菌株（Pe株）可导致脾脏和淋巴结重量及细胞数量增加三到四倍，感染后30-50天变化达到峰值。脾脏表现出明显的造血作用，单核吞噬细胞增加30倍，Lyt2+淋巴细胞增加两倍。淋巴结中单核吞噬细胞增加五倍，Lyt2+ T细胞增加四点五倍。单核吞噬细胞的增加显著改变了T细胞/巨噬细胞比例，这与体外对有丝分裂原和弓形虫抗原的细胞增殖减少有关。现在可以通过调节这些细胞类型的变化来研究单核吞噬细胞和T细胞亚群的细胞平衡改变与短暂性免疫功能障碍表达之间的关系。
