清醒猫体内刺激后的胃前列腺素分泌以及前列腺素合成酶抑制作用的效果
Stimulated gastric prostaglandin output, and the effect of inhibition of prostaglandin synthetase, in the conscious cat.
作者信息
Baker R, Jaffe B M, Shaw B, Venables C W
出版信息
J Physiol. 1981 Aug;317:21-8. doi: 10.1113/jphysiol.1981.sp013811.
Abstract
- In the conscious gastric fistula cat there was no correlation between the outputs of gastric acid and PGE secreted in response to incremental doses of pentagastrin and histamine acid phosphate. 2. PGE secreted in response to pentagastrin and histamine was not dose dependent. 3. Flurbiprofen significantly inhibited the gastric output of PGE but did not influence acid or pepsin secretion. Inhibition of PGE secretion was accompanied by evidence of gastric mucosal haemorrhage. 4. It is concluded that gastric juice PGE is unlikely to be involved in the physiological control of acid secretion.
摘要
- 在清醒胃瘘猫中，胃酸分泌量与对递增剂量的五肽胃泌素和磷酸组胺酸作出反应时分泌的前列腺素E（PGE）之间没有相关性。2. 对五肽胃泌素和组胺作出反应时分泌的PGE并非剂量依赖性。3. 氟比洛芬显著抑制胃中PGE的分泌，但不影响胃酸或胃蛋白酶的分泌。PGE分泌的抑制伴随着胃黏膜出血的迹象。4. 得出的结论是，胃液中的PGE不太可能参与胃酸分泌的生理控制。
相似文献
1
Stimulated gastric prostaglandin output, and the effect of inhibition of prostaglandin synthetase, in the conscious cat.清醒猫体内刺激后的胃前列腺素分泌以及前列腺素合成酶抑制作用的效果
J Physiol. 1981 Aug;317:21-8. doi: 10.1113/jphysiol.1981.sp013811.
2
Endogenous prostaglandins and gastric secretion in the cat.猫体内的内源性前列腺素与胃液分泌
J Physiol. 1978 May;278:451-60. doi: 10.1113/jphysiol.1978.sp012316.
3
Endogenous prostaglandins and stimulated gastric secretion in the cat: the effect of various secretory inhibitors.内源性前列腺素与猫的胃酸分泌：各种分泌抑制剂的作用
J Physiol. 1979 Jun;291:1-9. doi: 10.1113/jphysiol.1979.sp012794.
4
Exogenous prostaglandins and gastric secretion in the cat.猫体内的外源性前列腺素与胃液分泌
J Physiol. 1978 May;278:441-50. doi: 10.1113/jphysiol.1978.sp012315.
5
Prostaglandins alter the relationship between gastric hydrogen ion concentration and flow: evidence for stimulation of non-parietal secretion in the cat.前列腺素改变胃氢离子浓度与流量之间的关系：猫非壁细胞分泌受刺激的证据。
J Physiol. 1981 Jul;316:427-38. doi: 10.1113/jphysiol.1981.sp013798.
6
Are prostaglandins involved in somatostatin mediated inhibition of gastric secretion in the cat?前列腺素是否参与了生长抑素介导的猫胃分泌抑制过程？
Agents Actions. 1986 Apr;18(1-2):205-9. doi: 10.1007/BF01988022.
7
The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.生长抑素和甲硫咪特对清醒猫中五肽胃泌素刺激的胃酸和胃蛋白酶分泌快速耐受的影响。
J Physiol. 1977 Apr;266(3):801-17. doi: 10.1113/jphysiol.1977.sp011794.
8
Inhibition by prostaglandin E 1 of gastric secretion in the dog.前列腺素E1对犬胃液分泌的抑制作用。
J Physiol. 1971 Oct;218(2):369-83. doi: 10.1113/jphysiol.1971.sp009623.
9
Pepsin secretion in anaesthetized cats stimulated by pentagastrin and gastrin II in the presence or absence of secretin.在麻醉猫中，胃泌素五肽和胃泌素II在有无促胰液素存在的情况下刺激胃蛋白酶分泌。
J Physiol. 1979 Apr;289:1-7. doi: 10.1113/jphysiol.1979.sp012720.
10
Effects of histamine acid phosphate and pentagastrin on gastric secretion in normal human subjects.磷酸组胺和五肽胃泌素对正常人体受试者胃液分泌的影响。
Gut. 1970 May;11(5):395-404. doi: 10.1136/gut.11.5.395.
本文引用的文献
1
Effect of nerve stimulation on prostaglandin formation and release from the rat stomach.神经刺激对大鼠胃中前列腺素形成和释放的影响。
Am J Physiol. 1967 Oct;213(4):1056-64. doi: 10.1152/ajplegacy.1967.213.4.1056.
2
Indomethacin. Effect on gastric secretion, parietal cell population, and ulcer provocation in the dog.吲哚美辛。对犬胃分泌、壁细胞数量及溃疡诱发的影响。
Arch Surg. 1968 Nov;97(5):809-15. doi: 10.1001/archsurg.1968.01340050149024.
3
Prevention of duodenal ulcers by administration of prostaglandin E 2 (PGE 2 ).通过给予前列腺素E2（PGE2）预防十二指肠溃疡。
Scand J Gastroenterol. 1971;6(4):303-5. doi: 10.3109/00365527109181124.
4
Radioimmunoassay for prostaglandins.前列腺素的放射免疫测定法。
Science. 1971 Feb 5;171(3970):494-6. doi: 10.1126/science.171.3970.494.
5
Biosynthesis of prostaglandins E2 and F2-alpha from tritium-labelled arachidonic acid by rat stomach homogenates.大鼠胃匀浆从氚标记的花生四烯酸生物合成前列腺素E2和F2-α 。
Biochim Biophys Acta. 1970 Dec 15;218(3):539-42. doi: 10.1016/0005-2760(70)90017-2.
6
The separate determination of human pepsin and gastricsin.人胃蛋白酶和胃凝乳蛋白酶的单独测定
Proc Soc Exp Biol Med. 1966 Jul;122(3):700-4. doi: 10.3181/00379727-122-31231.
7
Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds.大鼠胃底中的前列腺素合成酶活性。L-去甲肾上腺素及相关化合物的激活作用。
Biochim Biophys Acta. 1972 Sep 7;280(1):161-71. doi: 10.1016/0005-2760(72)90221-4.
8
Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma.人血浆中前列腺素E、A和F的放射免疫分析测定
J Clin Invest. 1973 Feb;52(2):398-405. doi: 10.1172/JCI107196.
9
Effects of oral administration of PGE2 on gastric secretion and experimental peptic ulcerations.口服前列腺素E2对胃液分泌及实验性消化性溃疡的影响。
Prostaglandins. 1973 Jan;3(1):29-45. doi: 10.1016/0090-6980(73)90135-4.
10
Inhibition by prostaglandin E 1 of gastric secretion in the dog.前列腺素E1对犬胃液分泌的抑制作用。
J Physiol. 1971 Oct;218(2):369-83. doi: 10.1113/jphysiol.1971.sp009623.
Zotero 插件