Quilty P M, Kerr G R, Duncan W
Radiother Oncol. 1986 Dec;7(4):311-21. doi: 10.1016/s0167-8140(86)80060-3.
A group of 889 patients who completed radical X-ray therapy for transitional cell carcinoma of the bladder during a 12 year period were analysed by a multivariate technique. The patient's age, tumour category, tumour size and haemoglobin level were shown to be independent prognostic covariates. A prognostic index was derived and four prognostic subgroups were identified. The prognostic index could divide patients within each T category into those with good, moderate, fair or poor prognosis. The 5 year actuarial survival rate for patients in the poor prognosis group was 5.8% compared to 69.8% for patients in the good prognosis group. Durable local tumour control after radical radiotherapy was also analysed by a multivariate technique. Tumour category, grade, haemoglobin and urea level were found to be significant covariates. A tumour control index was derived and two groups were identified corresponding to a high probability of lasting local control after radical radiotherapy (47.8% of patients) or a low probability of control (52.2%).
采用多变量技术分析了一组889例在12年期间接受膀胱癌根治性X线治疗的患者。结果显示，患者的年龄、肿瘤类别、肿瘤大小和血红蛋白水平是独立的预后协变量。由此得出了一个预后指数，并确定了四个预后亚组。该预后指数可将每个T类别中的患者分为预后良好、中等、尚可或较差的患者。预后较差组患者的5年精算生存率为5.8%，而预后良好组患者为69.8%。还采用多变量技术分析了根治性放疗后持久的局部肿瘤控制情况。发现肿瘤类别、分级、血红蛋白和尿素水平是显著的协变量。由此得出了一个肿瘤控制指数，并确定了两组，分别对应根治性放疗后局部持久控制的高概率（47.8%的患者）或低概率（52.2%）。
